Airway epithelial Fas ligand expression: potential role in modulating bronchial inflammation

The American Journal of Physiology
B R GochuicoA Fine

Abstract

Epithelium-derived Fas ligand is believed to modulate inflammation within various tissues. In this paper, we report findings that suggest a similar immunoregulatory role for Fas ligand in the lung. First, Fas ligand was localized to nonciliated, cuboidal airway epithelial cells (Clara cells) throughout the airways in the normal murine lung by employing nonisotopic in situ hybridization and immunohistochemistry. Second, gld mutant mice, which express a dysfunctional Fas ligand protein, were noted to develop prominent infiltration of inflammatory cells in submucosal and peribronchial regions of the upper and lower airways. Third, during allergic airway inflammation induced by ovalbumin in mice, cell-associated staining for Fas ligand mRNA and protein was markedly reduced in the airway epithelium. These data suggest that Clara cell-derived Fas ligand may control immune activity in the airway; thus alterations in this protective mechanism may be involved in the pathogenesis of certain inflammatory conditions of the airway, such as asthma.

References

Jan 1, 1991·Annual Review of Immunology·P L Cohen, R A Eisenberg
May 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G Holt, C McMenamin
Nov 17, 1995·Science·T S GriffithT A Ferguson
Mar 1, 1994·The Journal of Clinical Investigation·E MyslerK B Elkon
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·S HanabuchiK Okumura
Sep 1, 1994·The Journal of Investigative Dermatology·K SayamaY Miki
Oct 19, 1995·Nature·D BellgrauR C Duke
Aug 26, 1993·Nature·J OgasawaraS Nagata
May 1, 1996·American Journal of Respiratory Cell and Molecular Biology·D I BlythD Fattah
May 1, 1996·American Journal of Respiratory and Critical Care Medicine·J S ErjefältC G Persson
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·D L Vaux, A Strasser
Mar 1, 1997·American Journal of Respiratory Cell and Molecular Biology·E M HesselF P Nijkamp
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·N KayagakiH Yagita

❮ Previous
Next ❯

Citations

Aug 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·A FineB D Uhal
Oct 29, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·M E De PaepeF I Luks
Apr 27, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·B R GochuicoA Fine
Oct 27, 2009·American Journal of Respiratory Cell and Molecular Biology·Jiankun TongAnne I Sperling
Jun 17, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·R A BemG Matute-Bello
Jan 28, 2006·American Journal of Respiratory Cell and Molecular Biology·Yohannes Tesfaigzi
Jul 4, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·G Matute-BelloT R Martin
Nov 13, 2004·Stem Cells·Osnat Bohana-Kashtan, Curt I Civin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

American Journal of Physiology. Lung Cellular and Molecular Physiology
S Z WangK S Harrod
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Henrik WidegrenLennart Greiff
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
F Broeckaert, A Bernard
© 2022 Meta ULC. All rights reserved