Airway Epithelial Lining Fluid and Plasma Pharmacokinetics of Inhaled Fluticasone Propionate and Salmeterol Xinafoate in Mechanically Ventilated Pigs.

Journal of Aerosol Medicine and Pulmonary Drug Delivery
Pär EwingPer Gerde

Abstract

Background: The lower respiratory tract of the landrace pig has close anatomical and physiological similarities with that of the human, and hence, for inhalation studies this species is well suited for biopharmaceutical research. Methods: The objective of this study was to evaluate pharmacokinetics in pigs following one dose of Diskus™ Seretide™ forte device, labeled 500/50 fluticasone propionate (FP) and salmeterol xinafoate (SX), respectively. The PreciseInhale™ (PI) instrument was used to actuate the inhaler for in vitro testing and aerosol dosing to pigs. In vitro, the aerosol was characterized with a cascade impactor with respect to mass median aerodynamic diameter, geometric standard deviation, and fine particle dose. In vivo, dry powder inhalation exposure was delivered as a short bolus dose, to anesthetized and mechanically ventilated landrace pigs. In addition to plasma PK, PK assessment of airway epithelial lining fluid (ELF) was used in this study. ELF of the depth of three to fourth airway generation of the right lung was accessed using standard bronchoscopy and a synthetic absorptive matrix. Results and Conclusions: Dry powder inhalation exposures with good consistency and well characterized aerosols to the pig lun...Continue Reading

References

Jun 1, 1976·Environmental Health Perspectives·H C YehO G Raabe
Jun 1, 1996·British Journal of Pharmacology·C FornhemK Alving
May 29, 2000·Journal of Pharmaceutical Sciences·P BrandK Häubetainger
Nov 7, 2001·Inhalation Toxicology·P Gerde, B R Scott
Feb 24, 2004·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Jolyon P Mitchell, Mark W Nagel
Apr 6, 2006·International Journal of Pharmaceutics·Walid Y TarsinHenry Chrystyn
Nov 28, 2012·Pharmaceutical Research·Claudia Suenderhauf, Neil Parrott
Feb 21, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Bo OlssonMårten Svensson
May 16, 2014·American Journal of Respiratory Cell and Molecular Biology·Eoin P JudgeShirley O'Dea
May 17, 2014·Nature Reviews. Drug Discovery·David CookMenelas N Pangalos
Jul 8, 2017·Pharmaceutical Research·Therese EricssonKen Grime
Oct 24, 2017·Critical Care : the Official Journal of the Critical Care Forum·Jonathan DugernierGregory Reychler
Dec 28, 2017·CPT: Pharmacometrics & Systems Pharmacology·Ramon HendrickxDouglas Ferguson
Mar 2, 2018·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Merja KirjavainenSatu Lähelmä

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Methods Mentioned

BETA
bronchoalveolar lavage
biopsy

Software Mentioned

PIs
LabVIEW
PI
Phoenix

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