Airway Epithelium Dysfunction in Cystic Fibrosis and COPD

Mediators of Inflammation
Virginia De RoseCatherine M Greene

Abstract

Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene, whereas chronic obstructive pulmonary disease (COPD) is mainly caused by environmental factors (mostly cigarette smoking) on a genetically susceptible background. Although the etiology and pathogenesis of these diseases are different, both are associated with progressive airflow obstruction, airway neutrophilic inflammation, and recurrent exacerbations, suggesting common mechanisms. The airway epithelium plays a crucial role in maintaining normal airway functions. Major molecular and morphologic changes occur in the airway epithelium in both CF and COPD, and growing evidence suggests that airway epithelial dysfunction is involved in disease initiation and progression in both diseases. Structural and functional abnormalities in both airway and alveolar epithelium have a relevant impact on alteration of host defences, immune/inflammatory response, and the repair process leading to progressive lung damage and impaired lung function. In this review, we address the evidence for a critical role of dysfunctional airway epithelial cells in chronic airway inflammation and remodelling in CF and COPD, highlighting the common mechanisms involved in the epithelial dy...Continue Reading

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Citations

Mar 21, 2020·Immunology·Rachele InvernizziPhilip L Molyneaux
Jul 3, 2020·International Journal of Environmental Research and Public Health·Giuliano MolinariElsa Nervo
Jul 29, 2020·International Journal of Molecular Sciences·Pascal DuchesneauGolnaz Karoubi
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Nov 13, 2020·Frontiers in Immunology·Elyse Y BissonnetteSteven F Ziegler
Apr 18, 2021·Cellular and Molecular Life Sciences : CMLS·Xue LiHuaiyong Chen
May 1, 2021·International Journal of Environmental Research and Public Health·Ersilia NigroAurora Daniele
Jul 20, 2021·Frontiers in Physiology·María Amparo BayarriJulio Cortijo
Apr 11, 2019·Journal of Innate Immunity·Jasmijn A SchrumpfPieter S Hiemstra

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Methods Mentioned

BETA
xenograft

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