Airway function in infants treated with inhaled nitric oxide for persistent pulmonary hypertension

Pediatric Pulmonology
Aparna U HoskoteJanet Stocks

Abstract

Inhaled nitric oxide (iNO), used for treatment of persistent pulmonary hypertension of newborn (PPHN), is an oxygen free radical with potential for lung injury. Deferring ECMO with iNO in these neonates could potentially have long-term detrimental effects on lung function. We studied respiratory morbidity (defined as occurrence of respiratory infections requiring treatment, episodes of wheezing, and/or need for ongoing medications following discharge) and airway function at 1 year postnatal age in term neonates treated with iNO but not ECMO for PPHN, and compared data from similar infants recruited to the UK ECMO Trial randomized to receive ECMO or conventional management (CM). Maximal expiratory flow at FRC (V(') (maxFRC)) was measured in infants treated with iNO for PPHN (oxygenation index >or=25) at birth. V(') (maxFRC) was measured in 23 infants and expressed as z-scores, to adjust for sex and body size and compared to data from 71 (46 ECMO, 25 CM) infants studied at a similar age in the ECMO Trial. Respiratory morbidity was low in iNO group. V(') (maxFRC) z-score was lower than predicted in all groups (P < 0.001), with no significant difference between those treated with iNO [mean (SD) z-score: -1.65 (1.2)] and those treat...Continue Reading

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Jan 20, 2012·Pediatric Research·Heather M ByersKristi S Borowski
Feb 18, 2010·Cardiology in Review·Usha Krishnan
Oct 5, 2010·Allergologia et immunopathologia·R Dinwiddie
Jan 17, 2009·Pediatric Pulmonology·Ah-Fong HooUNKNOWN INNOVO Trial Collaborating Group
Mar 25, 2009·Current Opinion in Pediatrics
May 7, 2009·Current Opinion in Anaesthesiology

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