Airway function, inflammation and regulatory T cell function in subjects in asthma remission.

Canadian Respiratory Journal : Journal of the Canadian Thoracic Society
Louis-Philippe BouletJamila Chakir

Abstract

Factors associated with asthma remission need to be determined, particularly when remission occurs in adulthood. To evaluate airway responsiveness and inflammation in adult patients in asthma remission compared with adults with mild, persistent symptomatic asthma. Adenosine monophosphate and methacholine responsiveness were evaluated in 26 patients in complete remission of asthma, 16 patients in symptomatic remission of asthma, 29 mild asthmatic patients and 15 healthy controls. Blood sampling and induced sputum were also obtained to measure inflammatory parameters. Perception of breathlessness at 20% fall in forced expiratory volume in 1 s was similar among groups. In subjects with symptomatic remission of asthma, responsiveness to adenosine monophosphate and methacholine was intermediate between mild asthma and complete asthma remission, with the latter group similar to controls. Asthma remission was associated with a shorter duration of disease. Blood immunoglobulin E levels were significantly increased in the asthma group, and blood eosinophils were significantly elevated in the complete asthma remission, symptomatic remission and asthma groups compared with controls. The suppressive function of regulatory T cells was lower...Continue Reading

Citations

Feb 24, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Piotr Z Brewczyński, Andrzej Brodziak
Jul 31, 2019·Journal of Clinical Medicine·Sara R A WijnantErnst R Rietzschel
May 7, 2020·Frontiers in Pediatrics·Michael B Anthracopoulos, Mark L Everard
Sep 6, 2018·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Li-Li LiuFu-Hai Li
Dec 24, 2019·The Journal of Allergy and Clinical Immunology·Andrew Menzies-GowChristopher S Ambrose
Jul 3, 2021·Allergy, Asthma & Immunology Research·Janette M BirminghamPaula J Busse

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