Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma

Immunology
Ivana KawikovaPhilip W Askenase

Abstract

Contact skin immunization of mice with reactive hapten antigen and subsequent airway challenge with the same hapten induces immediate airflow obstruction and subsequent airway hyper-reactivity (AHR) to methacholine challenge, which is dependent on B cells but not on T cells. This responsiveness to airway challenge with antigen is elicited as early as 1 day postimmunization and can be adoptively transferred to naïve recipients via 1-day immune cells. Responses are absent in 1-day immune B-cell-deficient JH(-/-) mice and B-1 B-cell-deficient xid male mice, as well as in recipients of 1-day immune cells depleted of cells with the B-1 cell phenotype (CD19(+) B220(+) CD5(+)). As B-1 cells produce immunoglobulin M (IgM), we sought and found significantly increased numbers of anti-hapten IgM-producing cells in the spleen and lymph nodes of 1-day immune wild-type mice, but not in xid mice. Then, we passively immunized naive mice with anti-hapten IgM monoclonal antibody and, following airway hapten challenge of the recipients, we showed both immediate airflow obstruction and AHR. In addition, AHR was absent in complement C5 and C5a receptor-deficient mice. In summary, this study of the very early elicited phase of a hapten asthma model ...Continue Reading

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Citations

Aug 11, 2005·Current Allergy and Asthma Reports·Marsha Wills-Karp, Joerg Koehl
Feb 17, 2006·Nature Immunology·Leonore A Herzenberg, James W Tung
Feb 5, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jae Ho LeeSang Sun Lee
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Jan 29, 2014·Respiratory Medicine·Mohammad Afzal KhanIsmail Saadoun
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Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Niyun JinWilli K Born
Nov 30, 2019·Clinical Reviews in Allergy & Immunology·Chao HuangZhigang Tian

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