Airway hyperreactivity in patients undergoing lung and heart/lung transplantation

The American Review of Respiratory Disease
J R MaurerN Zamel

Abstract

To assess airway reactivity in lung transplant patients, three heart/lung, three double lung, and eight single lung transplant patients underwent airway challenge tests. All patients were assessed by methacholine aerosol challenge and thirteen were also assessed by histamine aerosol challenge at least three months after transplant surgery. The airways of patients with bilaterally denervated lungs (heart/lung and double lung transplants) were significantly more reactive to both methacholine and histamine (p less than 0.01) than were the airways of patients with unilaterally denervated (single lung transplants) lungs. Inflammatory changes in the airway mucosal biopsies were minimal in three patients and absent in all others. These studies raise questions about the role of central innervation in the maintenance of normal airway function as well as the mechanisms of action of both methacholine and histamine in causing bronchoconstriction.

References

May 1, 1986·The New England Journal of Medicine·UNKNOWN Toronto Lung Transplant Group
Oct 1, 1987·Clinical Science·G B RhindN J Douglas
Jan 30, 1986·The New England Journal of Medicine·W White
Jan 1, 1974·The Journal of Allergy and Clinical Immunology·C E Reed
Jan 1, 1981·Lung·J B Richardson

❮ Previous
Next ❯

Citations

May 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Akira InguTomio Abe
May 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Chris WardPaul Corris
Mar 19, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marc EstenneSamuel Yousem
Apr 1, 1995·British Journal of Pharmacology·R Tavakoli, N Frossard
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·M B Stanbrook, S Kesten
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·A Van MuylemM Estenne
Jun 1, 1990·Chest·A R GlanvilleE D Robin
Jan 1, 1991·Respiratory Medicine·T HathawayJ Wallwork
Dec 1, 1991·The Annals of Thoracic Surgery·C E HobsonI L Kron
Apr 1, 1994·Chest·P V DicpinigaitisP L Almenoff
Jun 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Michael E BowdishMark L Barr
Apr 6, 2007·Journal of Applied Physiology·Chun Y Seow
Nov 1, 1993·The American Review of Respiratory Disease·T J HathawayJ Wallwork
May 1, 2007·Journal of Applied Physiology·Charles Irvin
Jan 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·H SchersténF N Nilsson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.