Airway hyperresponsiveness and acute chest syndrome in children with sickle cell anemia

Pediatric Pulmonology
Karl P SylvesterAnne Greenough


To determine the occurrence and magnitude of airway hyperresponsiveness (AHR) in children with sickle cell anemia (SCA) who had or had not had acute chest syndrome (ACS) episodes. A subsidiary aim was to determine whether cold air and exercise challenge testing gave similar results in children with SCA. AHR would be greater in SCA children who had had an ACS episode compared to those who had not. Prospective observational study. Forty-two SCA children (median age of 11.5 [range 6.1-16.8] years); 12 children had been previously hospitalized for an ACS episode. AHR was assessed by the change in forced expiratory volume in 1 sec (FEV1) to a cold air challenge and in a subset of the children to an exercise challenge. A positive result to either challenge was deemed to have occurred if the FEV1 fell by at least 10% from the pre-challenge baseline. The magnitude of change in FEV1 following the cold air challenge was similar in children who had or had not had an ACS episode. Six children had a positive response to the cold air challenge (AHR); none had had an ACS hospitalization. Similar proportions of children responded to the cold air and exercise challenge and the magnitude of response to the two tests was similar. Some children, h...Continue Reading


Feb 1, 1991·The American Review of Respiratory Disease·P PianosiA L Coates
Nov 1, 1990·The American Review of Respiratory Disease·S P BlackieP D Paré
Jun 9, 1994·The New England Journal of Medicine·O S PlattP P Klug
Mar 1, 1993·The American Review of Respiratory Disease·Y OosterhoffD S Postma
Aug 1, 1997·The Journal of Pediatrics·M A LeongJulian L Allen
Dec 24, 1998·The European Respiratory Journal·F SantoliG Atlan
Jun 22, 2000·The New England Journal of Medicine·O S Platt
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·L M van Den ToornJ C de Jongste
Nov 2, 2002·American Journal of Respiratory and Critical Care Medicine·Massimo CorradiEugenio Baraldi
Jul 27, 2004·Pediatric Pulmonology·Jessica H BoydMichael R DeBaun
Jan 25, 2005·Clinical and Molecular Allergy : CMA·Mark E NordnessKevin J Kelly
Jul 25, 2006·The Journal of Pediatrics·Karl P SylvesterAnne Greenough
Dec 23, 2006·Pediatric Pulmonology·Karl P SylvesterAnne Greenough
Mar 1, 1993·The European Respiratory Journal·P J SterkJ L Malo


May 14, 2008·Current Opinion in Pediatrics·Jason B Caboot, Julian L Allen
Apr 15, 2011·Anemia·Kathryn Blake, John Lima
Sep 9, 2008·American Journal of Respiratory and Critical Care Medicine·Joanna E MacLeanPadmaja Subbarao
Dec 17, 2009·Hematology·Joshua J Field, Michael R DeBaun
Jan 28, 2014·Paediatric Respiratory Reviews·Jason B Caboot, Julian L Allen
Oct 7, 2010·Chest·Rekha Vij, Roberto F Machado
Dec 23, 2015·The Journal of Clinical Investigation·Marthe-Sandrine Eiymo Mwa MpolloPunam Malik
Aug 2, 2008·Pediatric Pulmonology·Robert C StrunkMichael R DeBaun
May 17, 2011·British Journal of Haematology·Edwige Balayssac-SiransyPascal Bogui
Feb 1, 2014·Pediatric Blood & Cancer·Sara Christina SadreameliJohn J Strouse
Aug 5, 2014·American Journal of Hematology·Michael R DeBaunRobert C Strunk
Jul 10, 2013·Pediatric Pulmonology·Catherine J WedderburnAnne Greenough
Jul 29, 2009·Pediatric Blood & Cancer·M Paulina VelasquezGladstone E Airewele
Mar 29, 2013·Expert Opinion on Pharmacotherapy·Payal C Desai, Kenneth I Ataga
Dec 28, 2017·Pediatric Allergy, Immunology, and Pulmonology·Sara C SadreameliJohn J Strouse
Oct 27, 2007·Pediatric Pulmonology·Ozlem Yilmaz OzbekNamik Ozbek
Dec 19, 2007·Pediatric Pulmonology·Anastassios C KoumbourlisAda Lee
Sep 13, 2018·Blood·Evans M Machogu, Roberto F Machado
Sep 13, 2012·British Journal of Haematology·Jeffrey A GlassbergLynne D Richardson
Oct 1, 2011·Expert Review of Respiratory Medicine·Samuel O AnimMichael R DeBaun
Dec 15, 2016·Asthma Research and Practice·Robyn T CohenRobert C Strunk
May 16, 2019·Current Opinion in Pediatrics·Shaina M WillenMichael R DeBaun
Nov 27, 2020·Pediatric Pulmonology·Evans M MachoguStacey Peterson-Carmichael

Related Concepts

Acute Disease
Anemia, Sickle Cell
Cold Temperature
Cardiopulmonary Exercise Test
Lung Diseases
Respiratory Hypersensitivity

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