Airway inflammation in asymptomatic children with episodic wheeze

Pediatric Pulmonology
Carolyn MaclennanNicholas J Freezer

Abstract

Airway pathologies have been comprehensively researched in adult asthma, but in children, the extent of airway inflammation associated with episodic wheeze, often diagnosed as asthma, has not been fully characterized. It is not clear whether persistent airway inflammation is present in the absence of wheezing symptoms, and there is controversy regarding the role of age and atopy. This study assessed cellular and cytokine markers of airway inflammation in asymptomatic children with a history of episodic wheeze. Children with a history of episodic wheeze and cough (study group) and nonasthmatic patients requiring elective surgery (control group) were recruited. All subjects in the study group had a history of significant episodic wheezing (>2 episodes per year), and used only as-needed beta-agonist treatment. Bronchoalveolar lavage (BAL) was obtained using bronchoscopic lavage (study group) and nonbronchoscopic lavage (control group). Differential cell counts of BAL and flow cytometry were performed to identify T-lymphocyte phenotypes, and intracellular cytokine profiles were measured after phorbol-12-myristate 13-acetate (PMA) stimulation of BAL fluid T-cells. Twenty-one children with a history of 2-12 episodes of wheeze per yea...Continue Reading

References

Apr 1, 1992·The American Review of Respiratory Disease·J W WilsonS T Holgate
Feb 1, 1990·The American Review of Respiratory Disease·A J FrewM K Church
Dec 1, 1990·The American Review of Respiratory Disease·M AzzawiA B Kay
Aug 1, 1989·Archives of Disease in Childhood·R D CliffordS T Holgate
Jul 1, 1995·American Journal of Respiratory and Critical Care Medicine·J RiedlerC F Robertson
Oct 1, 1994·The European Respiratory Journal·F RatjenU Costabel
Nov 15, 1993·The Medical Journal of Australia·S Phin, R K Oates
Aug 1, 1994·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·V Gemou-EngesaethC J Corrigan
Jun 18, 1994·BMJ : British Medical Journal·P D Phelan
Sep 15, 1994·The New England Journal of Medicine·T HaahtelaA Sovijärvi
Mar 1, 1994·Irish Journal of Medical Science·D Phelan, T F Gorey
Jun 7, 1993·The Medical Journal of Australia·A F Isles, C F Robertson
Apr 1, 1996·American Journal of Respiratory Cell and Molecular Biology·N KrugP H Howarth
Jul 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L G HeaneyM Ennis
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·N N JarjourW J Calhoun
Jul 25, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E C StevensonM D Shields
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·S LimP J Barnes
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·C MarguetJ O Warner
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·A O MagnanD Vervloet
Mar 17, 2001·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·C MarguetJ O Warner
May 24, 2001·American Journal of Respiratory and Critical Care Medicine·M E KrawiecS E Wenzel
Sep 13, 2002·Chest·Muriel Le BourgeoisJacques de Blic
Nov 16, 2002·American Journal of Respiratory and Critical Care Medicine·Paul T KingStephen R Holdsworth
Jan 30, 2003·Thorax·B G Higgins, J G Douglas
Jan 20, 2005·American Journal of Respiratory and Critical Care Medicine·Sejal SaglaniPeter K Jeffery

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Citations

Apr 25, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I Leonard BernsteinUNKNOWN American College of Allergy, Asthma and Immunology
Jan 24, 2009·The New England Journal of Medicine·Jayachandran PanickarJonathan Grigg
Feb 5, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Czarina CalderonNicholas J Freezer
Aug 13, 2008·Paediatric Respiratory Reviews·Siobhain BrennanPeter D Sly
Feb 26, 2009·FEMS Immunology and Medical Microbiology·Avanish K VarshneyPawan Malhotra
Oct 16, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K E van WonderenG Ter Riet
Aug 2, 2016·American Journal of Respiratory and Critical Care Medicine·Clement L RenUNKNOWN ATS Ad Hoc Committee on Infants with Recurrent or Persistent Wheezing
Dec 26, 2015·The Lancet. Respiratory Medicine·Jonathan Grigg
Jan 24, 2014·Current Opinion in Allergy and Clinical Immunology·Avraham BeigelmanLeonard B Bacharier
Feb 23, 2018·Pediatric Pulmonology·Jose A Castro-RodriguezAndrew Bush
Jan 1, 2014·Clinical and Translational Allergy·Kristiina MalmströmMika J Mäkelä
Sep 5, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Miles Weinberger
Jul 2, 2014·Pediatrics·Dhenuka RadhakrishnanDouglas D Fraser

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