Airway inflammation in children and adolescents with bronchiolitis obliterans

Cytokine
Martin RosewichStefan Zielen

Abstract

Airway inflammation plays a major role in the progression of chronic lung diseases. The features of airway inflammation are not well defined among patients with cases of bronchiolitis obliterans (BO) that began in childhood. To investigate the sputum cell and cytokine profiles of stable cases of BO regarding lung function and the involvement of small airway disease (SAD). Twenty patients with BO (median age=14.5, range=7-23years) and 22 healthy controls (median age=16.5years, range=7-24years) were investigated. Lung function parameters and bronchial reversibility testing as well as sputum cell and cytokine profiles (IL-1β, IL-6, IL-8, TNF-α, IL-5, IFN-γ, and NFκB regulation) were analysed using quantitative RT-PCR and cytometric bead assay (CBA) in induced sputum. Patients with BO had significantly lower lung function values, including FVC, forced expiratory volume (FEV1), the Tiffeneau index (FEV1/VC), and MEF25, but increased functional residual capacity (RV/TLC) values. Bronchial reversibility was found in five patients (25%). Moreover, airway inflammation (as indicated by total cells, neutrophils, IL-1β, IL-6, IL-8, TNF-α, and NFκB) was significantly increased among patients with BO compared with controls. BO is predominant...Continue Reading

Associated Clinical Trials

References

May 2, 2000·Pediatric Pulmonology·L ZhangF A Abreu e Silva
Aug 9, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A Elssner, C Vogelmeier
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 29, 2004·Nature Immunology·Tomohiro WatanabeWarren Strober
Jan 7, 2005·Pediatric Pulmonology·Geoffrey Kurland, Peter Michelson
Jun 3, 2006·American Journal of Respiratory and Critical Care Medicine·Geert M VerledenDirk E Van Raemdonck
Dec 27, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Gerhard C HildebrandtErnst Holler
Feb 28, 2008·Pediatric Pulmonology·Salvatore CazzatoAlessandro Cicognani
May 14, 2008·Current Opinion in Pediatrics·Siby P Moonnumakal, Leland L Fan
Apr 22, 2009·Pediatric Pulmonology·Stacey L Peterson-CarmichaelStephanie D Davis
Jul 16, 2009·JAMA : the Journal of the American Medical Association·Kirsten M WilliamsSteven Z Pavletic
Nov 23, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C NeurohrUNKNOWN Munich Lung Transplant Group
Jan 7, 2011·Allergologia et immunopathologia·J MallolV Espinosa
Aug 30, 2011·Allergologia et immunopathologia·F De Baets
Nov 8, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B AntusE Csiszer
Jan 30, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V E KennedyS M Palmer
Sep 26, 2013·Frontiers in Microbiology·Hirokazu KimuraAkihide Ryo

❮ Previous
Next ❯

Citations

Sep 12, 2015·Jornal de pediatria·Jose Dirceu Ribeiro, Gilberto Bueno Fischer
Oct 30, 2016·Environmental Research·Ormrat KampeerawipakornMathuros Ruchirawat
Feb 26, 2019·Expert Review of Respiratory Medicine·Ema Kavaliunaite, Paul Aurora
Nov 19, 2015·Mucosal Immunology·U M ZisslerC B Schmidt-Weber
Dec 15, 2018·Pediatric Pulmonology·Alejandro J Colom, Alejandro M Teper
Feb 23, 2020·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Silvija-Pera JerkicMartin Rosewich
Dec 31, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Olaf EickmeierStefan Zielen
Nov 12, 2020·Pediatric Pulmonology·Kate C ChanAlbert M Li
Dec 12, 2020·Pediatric Pulmonology·Jae Hwa JungKyung Won Kim
Feb 9, 2021·Frontiers in Pediatrics·Diane M GrayAneesa Vanker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.