Airway Macrophage and Dendritic Cell Subsets in the Resting Human Lung

Critical Reviews in Immunology
Vineet Indrajit Patel, Jordan Patrick Metcalf

Abstract

Dendritic cells (DCs) and macrophages (MΦs) are antigen-presenting phagocytic cells found in many peripheral tissues of the human body, including the blood, lymph nodes, skin, and lung. They are vital to maintaining steady-state respiration in the human lung based on their ability to clear airways while also directing tolerogenic or inflammatory responses based on specific stimuli. Over the past three decades, studies have determined that there are multiple subsets of these two general cell types that exist in the airways and interstitium. Identifying these numerous subsets has proven challenging, especially with the unique microenvironments present in the lung. Cells found in the vasculature are not the same subsets found in the skin or the lung, as demonstrated by surface marker expression. By transcriptional profiling, these subsets show similarities but also major differences. Primary human lung cells and/ or tissues are difficult to acquire, particularly in a healthy condition. Additionally, surface marker screening and transcriptional profiling are continually identifying new DC and MΦ subsets. While the overall field is moving forward, we emphasize that more attention needs to focus on replicating the steady-state microe...Continue Reading

Citations

Jan 23, 2020·American Journal of Respiratory Cell and Molecular Biology·Saleela M RuwanpuraPhilip G Bardin
Aug 1, 2020·Frontiers in Cellular and Infection Microbiology·Malgorzata E MnichNina M van Sorge
May 24, 2020·Antioxidants & Redox Signaling·Giuseppe ValacchiPablo Evelson
Dec 18, 2020·American Journal of Respiratory Cell and Molecular Biology·Abigail M ShotlandAmy S McKee
May 11, 2021·Current Allergy and Asthma Reports·Marissa A GuttenbergRobert M Tighe
Aug 17, 2021·Frontiers in Public Health·Emmanuelle LogetteHenry Markram
Aug 29, 2021·Pathogens·Lisa J M SlimmenWendy W J Unger

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