Airway Mucin Secretion

Annals of the American Thoracic Society
Ana M JaramilloBurton F Dickey

Abstract

Exocytosis of secreted mucins is the final step in their intracellular processing, resulting in their release into the airway lumen to interact with water and ions to form mucus. Mucins are secreted at a low baseline rate and a high stimulated rate, and both rates are regulated by second messengers acting on components of the exocytic machinery. The principal physiologic function of the low baseline rate is to support steady-state mucociliary clearance of inhaled particles and pathogens that enter the airways during normal breathing. Even in the setting of mucin hyperproduction, baseline secretion generally does not induce mucus occlusion. The principal physiologic function of the high stimulated rate of secretion from both submucosal glands and surface goblet cells in proximal airways appears to be to sweep away larger particles, whereas in distal airways it appears to act in concert with mucin hyperproduction to induce mucus occlusion to trap migrating helminths. Pathophysiologically, stimulated mucin secretion in the setting of mucin hyperproduction from allergic or other types of airway inflammation in the absence of helminth infection causes airflow obstruction and infection. Molecular components of the mucin exocytic mach...Continue Reading

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Citations

Nov 16, 2018·Annals of the American Thoracic Society·Burton F Dickey
Nov 13, 2019·Pediatric Pulmonology·Cameron Bradley MorrisonCamille Ehre
Mar 7, 2020·Expert Review of Respiratory Medicine·Federica Lo BelloGaetano Caramori
Jul 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hee-Sung ChaeYoung-Won Chin
Aug 21, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brandon W LewisYogesh Saini
Dec 15, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kai LiuJia Luo
Nov 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Waldemar BuchwaldPrzemysław Ł Mikołajczak
Jun 3, 2021·International Journal of Molecular Sciences·Michael C McKelveyClifford C Taggart
Aug 11, 2021·Current Biology : CB·Abigail McShaneKatharina Ribbeck

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