PMID: 8964736Mar 1, 1996Paper

Airway obstruction during sleep increases blood pressure without arousal

Journal of Applied Physiology
C P O'DonnellJ L Robotham

Abstract

Recent studies suggest that arousal is the dominant factor acutely increasing blood pressure in obstructive sleep apnea and that neither stimulation of chemoreceptors nor mechanical factors associated with large negative swings in intrapleural pressure substantially contribute to the rise in blood pressure associated with each obstructive apneic event. A canine model of obstructive sleep apnea was used to examine the relative contributions of these mechanisms in the blood pressure response to induced airway obstruction during non-rapid-eye-movement sleep. In part A of the study, the arousal response was eliminated from an obstructive event by restoring airway patency just before the expected arousal, allowing blood pressure responses to be compared between obstructive events with and without arousal. In part B of the study, the protocol of Part A was repeated after pharmacological blockade of the autonomic nervous system with hexamethonium (20 mg/kg iv), eliminating neurally mediated responses due to arousal, stimulation of chemoreceptors, or other reflexes, while maintaining any mechanical effects on blood pressure related to swings in intrapleural pressure. The results of part A (n = 4 dogs) show that obstructive apneic event...Continue Reading

Citations

Feb 6, 1998·Journal of Applied Physiology·C R WilsonJ A Dempsey
Jan 7, 1998·Journal of Applied Physiology·H SchneiderC P O'Donnell
Mar 10, 2000·Journal of Applied Physiology·H SchneiderC P O'Donnell
Sep 28, 2000·Journal of Applied Physiology·L Chen, S M Scharf
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·R S Leung, T D Bradley
Dec 4, 2002·The Journal of Clinical Hypertension·Thomas G Pickering
Jan 21, 2010·Physiological Reviews·Jerome A DempseyChristopher P O'Donnell
Aug 7, 2014·Current Hypertension Reports·Meghna P MansukhaniVirend K Somers
Jul 19, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Meghna P MansukhaniVirend K Somers
Feb 14, 1998·Journal of Applied Physiology·S KatragaddaB J Morgan
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·D J GottliebM W Mahowald
Aug 5, 2000·Journal of Applied Physiology·P R EastwoodJ A Dempsey
Oct 3, 2002·American Journal of Respiratory and Critical Care Medicine·Christopher P O'DonnellAlan R Schwartz
Jul 7, 2010·Expert Review of Cardiovascular Therapy·Kim H Chan, Ian Wilcox
Nov 16, 2011·Pflügers Archiv : European journal of physiology·Richard S T LeungDaniel Stevens
Oct 9, 2015·American Journal of Respiratory Cell and Molecular Biology·Swati ChopraJonathan C Jun
Apr 8, 1999·American Journal of Respiratory and Critical Care Medicine·G Lorenzi-FilhoT D Bradley
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·M W Mahowald
Nov 27, 2018·Sleep·David Barros, Francisco García-Río
Oct 7, 2019·Physiological Reports·Megan B BlackburnKathy L Ryan
Apr 8, 1999·Journal of Applied Physiology·L ChenS M Scharf
Oct 20, 2001·Journal of Applied Physiology·A AnandJ W Weiss
Mar 10, 2000·Journal of Applied Physiology·H SchneiderC P O'Donnell
Mar 11, 2011·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Silvio MusmanSandhi Maria Barreto
Jul 6, 2014·Sleep Disorders·Kirsi VäyrynenSari-Leena Himanen
Sep 22, 2015·Current Opinion in Pulmonary Medicine·Milan Minic, Clodagh M Ryan
Jun 3, 2008·Sleep Medicine Clinics·Jonathan Jun, Vsevolod Y Polotsky

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