Airway-parenchymal interdependence after airway contraction in rat lung explants

Journal of Applied Physiology
A AdlerD H Eidelman

Abstract

The constriction of pulmonary airways is limited by the tethering effect exerted by parenchymal attachments. To characterize this tethering effect at the scale of intraparenchymal airways, we studied the pattern of parenchymal distortion due to bronchoconstriction in a rat lung explant system. First, we measured the elastic modulus under tension for 2% (wt/vol) agarose alone (37.6 +/- 1.5 kPa) and for agarose-filled lung (5.7 +/- 1.3 kPa). The latter is similar to the elastic modulus of air-filled lung at total lung capacity (4.5-6 kPa) (S. J. Lai-Fook, T. A. Wilson, R. E. Hyatt, and J. R. Rodarte. J. Appl. Physiol. 40: 508-513, 1976), suggesting that explants can be used as a model of lung tissue distortion. Subsequently, confocal microscopic images of fluorescently labeled 0.5-mm-thick explants prepared from agarose-filled rat lungs inflated to total lung capacity (48 ml/kg) were acquired. Images were taken before and after airway constriction was induced by direct application of 10 mM methacholine, and the pattern of parenchymal distortion was measured from the displacement of tissue landmarks identified in each image for 14 explants. The magnitude of the radial component of tissue displacement was calculated as a function o...Continue Reading

References

Mar 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S J Lai-Fook
Apr 1, 1976·Journal of Applied Physiology·S J Lai-FookJ R Rodarte
Oct 1, 1990·Physiological Reviews·D Stamenović
Dec 1, 1988·Journal of Applied Physiology·D Stamenovic, D Yager
Mar 1, 1987·Journal of Applied Physiology·D J DingP T Macklem
Jan 1, 1973·Journal of Applied Physiology·R K Lambert, T A Wilson
Oct 1, 1972·Journal of Applied Physiology·T A Wilson
May 1, 1970·Journal of Applied Physiology·J MeadD Leith
Jun 1, 1971·Journal of Applied Physiology·T SugiharaJ Hildebrandt
Jul 1, 1993·Journal of Applied Physiology·R J DandurandD H Eidelman
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·P T Macklem

❮ Previous
Next ❯

Citations

Jul 18, 2001·Journal of Applied Physiology·F C CorreaP R Rocco
Jan 9, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen E McGowanJennifer Smith
Apr 14, 2012·Journal of Applied Physiology·Baoshun Ma, Jason H T Bates
Jan 14, 1999·Journal of Applied Physiology·F G Salerno, M S Ludwig
Jan 6, 2007·Journal of Applied Physiology·Jason H T Bates, Anne-Marie Lauzon
Nov 25, 2011·Journal of Applied Physiology·Jian ZhouSteven C George
Jun 28, 2016·International Journal for Numerical Methods in Biomedical Engineering·Lena YoshiharaWolfgang A Wall
Aug 26, 2016·Frontiers in Physiology·Jonathan E HiornsBindi S Brook
Feb 16, 2018·Journal of Applied Physiology·Jason H T Bates, Vignesh Rajendran
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·T UhligP D Sly
Feb 1, 2014·Journal of Applied Physiology·Baoshun Ma, Jason H T Bates
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·A DuguetR S Tepper
Mar 17, 2006·Journal of Applied Physiology·Ewald R Weibel
Nov 11, 2006·American Journal of Respiratory and Critical Care Medicine·Michelle A CareyDarryl C Zeldin
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·S KononovB Suki
Feb 14, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·P Scandiucci de FreitasA U Daniels
Apr 29, 2006·Journal of Applied Physiology·James P Butler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Respiratory Physiology & Neurobiology
Baoshun MaJason H T Bates
Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace
F G SalernoA Spanevello
© 2022 Meta ULC. All rights reserved