PMID: 8958893Nov 1, 1996Paper

Airway response of asthmatic subjects to inhaled allergen after exposure to pollutants

Thorax
C RusznakR J Davies

Abstract

Recent studies have suggested that air pollutants resulting from vehicle exhaust emissions and burning of fossil fuels, either in combination or individually, may enhance the airway response of asthmatic subjects to inhaled allergen. It was hypothesised that the airway response to inhaled allergen after exposure to a combination of 400 ppb nitrogen dioxide (NO2) and 200 ppb sulphur dioxide (SO2) is increased 24-48 hours after exposure. Thirteen mild atopic asthmatic volunteers were exposed for six hours to a single exposure of air and three exposures of the combination of 400 ppb NO2 + 200 ppb SO2 in randomised order, and then challenged with increasing concentrations of Dermatophagoides pteronyssinus allergen either immediately after exposure to air, or immediately, 24 hours or 48 hours after exposure to the combination of the two pollutants, until a 20% fall in forced expiratory volume in one second (FEV1) was recorded. Exposure to 400 ppb NO2 + 200 ppb SO2 significantly decreased the dose of D pteronyssinus allergen required to produce a 20% fall in FEV1 (PD20FEV1) at all times after exposure when compared with air. The mean percentage changes in allergen PD20FEV1 immediately, 24 hours, and 48 hours after exposure to 400 ppb...Continue Reading

Citations

Mar 24, 1999·Revue des maladies respiratoires·G PauliF De Blay
Jan 5, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J RingH Behrendt
Oct 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·P CrimiG Ciprandi
Dec 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S L Spector
Feb 27, 2008·Journal of Exposure Science & Environmental Epidemiology·James S BrownTerry Gordon
May 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C RusznakR J Davies
Jan 1, 1997·Allergy·R J DaviesJ L Devalia
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·A J VennJ Britton
Oct 6, 2005·Archives of Environmental Health·Richard T BurnettTom Dann
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M T Krishna, S T Holgate
Feb 13, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J DaviesJ L Devalia
Dec 13, 2005·Journal of Occupational and Environmental Medicine·Allyson WittenJohn Balmes
Feb 11, 2005·Epidemiology·Jennifer L PeelHoward Frumkin
Oct 14, 2003·Environmental and Molecular Mutagenesis·Stefania PaciniPiero Dolara
Jan 21, 2016·International Journal of Environmental Health Research·Anna-Sara ClaesonSteven Nordin
Feb 1, 1997·Chest·R J DaviesC Rusznak
Jun 12, 2012·Environmental Research·Janvier GasanaEdgar Ramos Vieira
Jul 1, 1997·Clinical Reviews in Allergy & Immunology·C RusznakR J Davies

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