Airway responses to nitrogen dioxide in asthmatic subjects

Journal of Toxicology and Environmental Health
V Mohsenin

Abstract

Nitrogen dioxide is a common indoor air pollutant. In order to characterize the respiratory responses to this gas, 10 asthmatics (mean age +/- SD = 30 +/- 8 yrs) were exposed to air and 0.5 ppm NO2 gas for 1 h in a 30-m3 environmental chamber on different days in a double-blind randomized fashion. The forced vital capacity, (VC), functional residual capacity, forced expiratory volume in 1 s, partial expiratory flow at 40% VC (Vp 40), and specific airway conductance were measured before and after exposure. Airway reactivity to methacholine inhalation was determined after each exposure. The dose of methacholine in milligrams per milliliter to cause a 40% decrease in Vp 40 was measured. None of the subjects reported any significant symptoms after exposure. Significant potentiation of airway reactivity was noted after NO2 exposure in asthmatic subjects as a group [PD40(AIR) = 9.2 +/- SD 15.0 versus PD40(NO2) = 4.6 +/- SD 8.2 mg/ml, p = 0.042]. No significant changes were noted in other lung functions after NO2 exposure. These findings indicate that asthmatics exposed to 0.5 ppm NO2 develop heightened airway reactivity.

References

Apr 1, 1978·Environmental Research·L J FolinsbeeJ C Delehunt
Jul 1, 1985·Archives of Environmental Health·W S LinnJ D Hackney
Jul 1, 1973·Journal of Applied Physiology·J Virgulto, A Bouhuys
Mar 1, 1972·Archives of Environmental Health·R J StephensM J Evans
Jun 1, 1969·The Journal of Clinical Investigation·A BouhuysA Zapletal
Mar 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M J HazuchaP A Bromberg
Oct 1, 1983·Journal of Toxicology and Environmental Health·M T KleinmanJ D Hackney
Jul 1, 1961·Journal of Applied Physiology·J A NADEL, D F TIERNEY
Jan 1, 1968·The Journal of Clinical Investigation·J HollandD V Bates

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Citations

Jun 7, 2002·The Science of the Total Environment·Hsiu-Ling ChenLi-Lin Lin
May 1, 1988·Archives of Environmental Health·V Mohsenin
Dec 14, 1991·BMJ : British Medical Journal·F Godlee
Jun 1, 1991·American Journal of Public Health·B D OstroJ C Selner
Apr 22, 2014·Environmental Health Perspectives·Véronique EzrattyMichel Aubier
Feb 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A J Wardlaw
Apr 1, 1993·Environmental Health Perspectives·L J Folinsbee
Mar 1, 1991·The American Review of Respiratory Disease·M W FramptonM J Utell
Oct 27, 2009·Critical Reviews in Toxicology·Julie E GoodmanMara Seeley
Oct 27, 2009·Critical Reviews in Toxicology·Thomas W HesterbergPeter A Valberg
Oct 1, 1992·The Journal of Allergy and Clinical Immunology·W E Pierson, J Q Koenig
Jul 28, 2015·Journal of the Air & Waste Management Association·Clement J CrosRichard L Corsi
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M T Krishna, S T Holgate
Sep 17, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G D'AmatoS Holgate
May 31, 2018·Indian Journal of Pediatrics·Sankaran Krishnan, Sherin Panacherry
Apr 15, 1991·The Medical Journal of Australia·M Abramson, T Voigt

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