PMID: 8959356Dec 1, 1996Paper

Airway responsiveness and atopy in families of patients with asthma

Clinical and Investigative Medicine. Médecine Clinique Et Experimentale
Catherine Laprise, L P Boulet

Abstract

To determine whether there is an increased prevalence and degree of airway hyperresponsiveness (AHR) and atopy in families of patients with asthma. Case-control study. Asthma clinic and surrounding community. A group of 28 families (n = 122) with one member who had attended the asthma clinic and a control group of 28 families (n = 122) from the same community. Each family member completed a questionnaire and underwent expiratory flow measurement, skin prick tests for allergies, methacholine tests and measurement of total serum IgE level and blood eosinophil count. Presence of atopy and AHR and relations between asymptomatic AHR or asthma and atopy, serum IgE levels or blood eosinophil counts. The group of families with a member with asthma had an increased prevalence of atopy and AHR, lower PC20 methacholine and higher serum IgE levels in comparison with controls, even when the first identified family members with asthma and their matched controls were not included. The subjects with atopy in the group with a patient with asthma had higher atopic indices and serum IgE levels than those in the control group, in whom asymptomatic AHR was less closely related to atopy. There was a significant correlation between PC20 methacholine ...Continue Reading

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