Abstract
The protection afforded by long-acting beta(2)-agonists against bronchoconstrictor stimuli can be regarded as a surrogate for their stabilizing effects on airway smooth muscle. To determine the magnitude of residual bronchoprotection after chronic dosing with long-acting beta(2)-agonists. Retrospective meta-analysis. Medline, BIDS and Cochrane Library databases were searched from 1990. A meta-analysis was then performed of 13 eligible randomized placebo-controlled trials (596 patients) in which second-line treatment with a long-acting beta(2)-agonist (salmeterol or formoterol) was used for 1 week or more. The residual protection against bronchoconstrictor stimuli as doubling dose/dilution shift was the main outcome measure. Data were assessed according to Quorum criteria. Combining the results of the meta-analysis, the overall estimated protection amounted to a 0.79 (95%CI 0.63-0.96) doubling dose/dilution shift from placebo. Subgroup analysis showed greater protection at peak vs. trough, but no difference between formoterol vs. salmeterol, or between direct vs. indirect challenge. There was no evidence of significant heterogeneity across all the studies, or within any of the subgroups. When used as second-line treatment, the o...Continue Reading
Citations
Apr 5, 2005·The Journal of Allergy and Clinical Immunology·Daniel K C LeeBrian J Lipworth
Jan 17, 2014·The Lancet. Respiratory Medicine·Donald W Cockcroft, Malcolm R Sears
Mar 25, 2008·Therapeutics and Clinical Risk Management·Graeme P CurrieDaniel Kc Lee
Feb 25, 2005·QJM : Monthly Journal of the Association of Physicians·G P CurrieD K C Lee
Jun 4, 2011·Chest·Karine L ClearieBrian J Lipworth
Apr 4, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Arvind ManoharanBrian J Lipworth
Feb 5, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C S Ulrik, Z Diamant
Aug 29, 2006·Lancet·Klaus F RabeUmesh G Lalloo
May 10, 2005·Respiratory Medicine·Graeme P CurrieAndrew M Wilson
Jan 7, 2009·Therapeutic Advances in Respiratory Disease·Bertil Lindmark
Nov 4, 2017·The European Respiratory Journal·Brian J Lipworth, Sunny Jabbal
Jul 1, 2006·Expert Review of Clinical Immunology·Graeme P Currie
Jul 21, 2004·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Graeme P CurrieBrian J Lipworth
Jul 29, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Graeme P CurrieBrian J Lipworth
Mar 9, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Catherine M Jackson, Brian Lipworth
Jun 6, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Brian LipworthChris RuiWen Kuo
Feb 7, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Brian LipworthRory Chan
May 10, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Daniel R MoralesHuan Wang