Airway stem cells: review of potential impact on understanding of upper airway diseases

The Laryngoscope
Fenggang YuDe-Yun Wang

Abstract

Epithelial remodeling is a part of our natural defense mechanisms, and includes migration, proliferation, and differentiation of epithelial cells, as well as the interactions between epithelial and stromal cells. It is not yet possible to distinguish between cause and effect during epithelium remodeling, and are there no clear roles for the many factors involved in respiratory infectious and inflammatory diseases due to a lack of critical information about epithelial cell responses. Most reported data are from lower airway studies or animal models. Therefore, research based on human nasal epithelial stem/progenitor cells can illuminate the pathophysiology of nasal airway disease from a different, more specific perspective. In this review, we discuss epithelial stem/progenitor cell research throughout the airway, with special attention to phenotypes and characterization of these cells from the nasal airway. Recently, we have isolated and cultured P63-positive human epithelial stem/progenitor cells from turbinate biopsies of healthy volunteers and from inflamed mucosa of patients with chronic rhinosinusitis with and without nasal polyposis. These cells propagate in serum-free, growth factor-supplemented, Dulbecco's modified Eagle...Continue Reading

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Citations

Dec 12, 2012·Current Allergy and Asthma Reports·Chunwei LiDe-Yun Wang
Jul 13, 2013·International Immunopharmacology·Mingjin YangYoufan Jiang
Sep 10, 2014·The Journal of Allergy and Clinical Immunology·Ying Ying LiDe Yun Wang
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Sep 24, 2020·International Journal of Molecular Sciences·Emanuela ChiarellaMaria Mesuraca
Aug 11, 2020·Clinical and Experimental Otorhinolaryngology·Se Hwan HwangAlexander Revzin

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