Airway subsensitivity with long-acting beta 2-agonists. Is there cause for concern?

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
B J Lipworth

Abstract

Regular treatment with both long- and short-acting beta 2-agonists results in tolerance to their bronchoprotective effects, although the relevance of this phenomenon in terms of long term asthma control remains unclear. However, there appears to be no appreciable difference between the 2 long-active beta 2-agonists, salmeterol and formoterol, in their propensity to induce beta 2-adrenoceptor down-regulation and subsensitivity. The degree of subsensitivity appears to be somewhat greater with indirect stimuli such as exercise and allergen challenge, compared with direct stimuli such as histamine and methacholine. This loss of functional antagonism with long-acting beta 2-agonist therapy is partial and is not prevented by concomitant inhaled corticosteroid therapy. However, the protective effects of inhaled corticosteroids on their own appear to be additive to those of long-acting beta 2-agonists when both drugs are concomitantly administered in the long term. The subsensitivity to bronchoprotection may be of clinical relevance in terms of patients who are inadvertently exposed to indirect bronchoconstrictor stimuli such as allergens or exercise, suggesting that long-acting beta 2-agonists should not be taken on a regular basis fo...Continue Reading

Citations

Aug 29, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·George BenschUNKNOWN International Study Group on Foradil Evaluation in Pediatric Asthma
Jul 10, 2003·Pulmonary Pharmacology & Therapeutics·Mario Cazzola, Maria Gabriella Matera
Jan 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Long P NguyenRichard A Bond
Jan 27, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaofeng JiangQuan Lu
Nov 20, 2013·Current Opinion in Pulmonary Medicine·Maria L DowellRamaswamy Krishnan
Dec 23, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Bryce N FeltisE Haydn Walters
Aug 12, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gustavo NinoMichael M Grunstein
Jun 12, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Steven S AnStephen B Liggett
Jan 6, 2012·International Journal of Otolaryngology·Gustavo NinoMichael Schwartz
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·P M O'ByrneA Tattersfield
Dec 4, 2012·American Journal of Respiratory Cell and Molecular Biology·Vaidehi J ThanawalaRichard A Bond
Mar 10, 2010·BMC Pulmonary Medicine·Gregory FeldmanUNKNOWN INLIGHT 1 study group
Sep 27, 2003·Paediatric Drugs·David Coghlan, Colin Powell
Jan 22, 2005·Treatments in Respiratory Medicine·Sandra D Anderson
Nov 14, 2013·American Journal of Respiratory Cell and Molecular Biology·Kathryn S RobinettStephen B Liggett
Jul 25, 2013·Pharmacology & Therapeutics·Delphine GrasArnaud Bourdin
Jun 26, 2001·European Journal of Drug Metabolism and Pharmacokinetics·M G DerksC J Van Boxtel
Dec 1, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jaro Ankerst
Apr 13, 2013·Expert Opinion on Therapeutic Targets·Stephen B Liggett
Jul 1, 2008·Expert Review of Clinical Immunology·Jeffrey B Rubins
Jun 17, 1998·The American Journal of Medicine·B LipworthD Hendrick
Jul 19, 2005·Expert Opinion on Investigational Drugs·Mario CazzolaJan Lötvall
Jun 3, 2004·Primary Care·Stephen H Landy
Mar 17, 2001·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M T HuangB L Chiang
Jun 21, 2005·Pulmonary Pharmacology & Therapeutics·Mario Cazzola
May 23, 2015·The Cochrane Database of Systematic Reviews·Kayleigh M KewShaleen Ahmad
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Christopher J Cates, Toby J Lasserson
Jun 20, 2015·The Cochrane Database of Systematic Reviews·Shaleen AhmadRebecca Normansell
Feb 20, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Donghwa KimStephen B Liggett
Apr 20, 2012·The Cochrane Database of Systematic Reviews·Christopher J Cates, Matthew J Cates
Jul 23, 2008·The Cochrane Database of Systematic Reviews·Christopher J Cates, Matthew J Cates

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