Airways exudation of plasma macromolecules: Innate defense, epithelial regeneration, and asthma

The Journal of Allergy and Clinical Immunology
Carl G A Persson

Abstract

This review discusses in vivo airway aspects of plasma exudation in relation to current views on epithelial permeability and epithelial regeneration in health and disease. Microvascular-epithelial exudation of bulk plasma proteins characteristically occurs in asthmatic patients, being especially pronounced in those with severe and exacerbating asthma. Healthy human and guinea pig airways challenged by noninjurious histamine-leukotriene-type autacoids also respond through prompt mucosal exudation of nonsieved plasma macromolecules. Contrary to current beliefs, epithelial permeability in the opposite direction (ie, absorption of inhaled molecules) has not been increased in patients with asthma and allergic rhinitis or in acutely exuding healthy airways. A slightly increased subepithelial hydrostatic pressure produces such unidirectional outward perviousness to macromolecules. Lack of increased absorption permeability in asthmatic patients can further be reconciled with occurrence of epithelial shedding, leaving small patches of denuded basement membrane. Counteracting escalating barrier breaks, plasma exudation promptly covers the denuded patches. Here it creates and sustains a biologically active barrier involving a neutrophil-r...Continue Reading

Citations

Dec 4, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Carl Persson
Oct 12, 2019·The European Respiratory Journal·Pieter S Hiemstra, Peter J Sterk
Feb 2, 2021·Scandinavian Journal of Immunology·Carl Persson
Mar 7, 2021·The Journal of Allergy and Clinical Immunology·Lei FangMichael Roth
Jun 29, 2021·Clinical & Translational Immunology·Qiyun MaMingshun Zhang
Mar 24, 2020·Journal of Innate Immunity·Carl Persson

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BETA
bronchoalveolar lavage

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