PMID: 11920968Mar 29, 2002Paper

Airways inflammation after exposure in a swine confinement building during cleaning procedure

American Journal of Industrial Medicine
Britt-Marie LarssonLena Palmberg

Abstract

Healthy volunteers exposed for 3 hr during weighing of pigs develop an airway inflammation characterized by a massive influx of neutrophilic granulocytes in the upper and lower airways and increased bronchial responsiveness to methacholine. The purpose of the present study was to investigate health effects from exposure during cleaning of the swine confinement building and to evaluate the effect of a respiratory protection device. Sixteen subjects were exposed for 3 hr during cleaning of a swine confinement room with a high-pressure cleaner. Seven out of sixteen subjects were equipped with a mask during exposure. The bronchial responsiveness increased in all subjects following exposure, significantly more in the group exposed without a mask (P < 0.05). The cell concentration (mainly neutrophilic granulocytes) in nasal lavage fluid as well as the concentration of interleukin-8, increased significantly only in those subjects exposed without a respiratory protection device. In peripheral blood, an increase of neutrophilic granulocytes was observed in both groups, although it was significantly higher in the group without mask (P < 0.05). The inhalable dust level was 0.94 (0.74 - 1.55) mg/m(3) and respirable dust 0.56 (0.51-0.63) mg...Continue Reading

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Citations

Dec 4, 2012·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Sara MayJill A Poole
Mar 20, 2012·The Annals of Occupational Hygiene·Patrick O'ShaughnessyKevin Kelly
Feb 19, 2009·Occupational Medicine·Melissa R MazanAndrew M Hoffman
Jul 24, 2004·American Journal of Respiratory and Critical Care Medicine·Frédéric GirardCatherine Lemière
Jun 8, 2006·Journal of Occupational Medicine and Toxicology·Chandrashekhar Charavaryamath, Baljit Singh
Aug 17, 2004·Srpski arhiv za celokupno lekarstvo·Slavisa DjuricićMihail Gavrilov
Sep 18, 2004·American Journal of Industrial Medicine·Lena PalmbergKjell Larsson
Apr 1, 2006·Journal of Applied Physiology·Israel Rubinstein, Susanna G Von Essen
Jul 10, 2020·Clinical and Translational Allergy·T SigsgaardA Siracusa
Nov 8, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Toby K McGovernMikael Adner

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