PMID: 8584241Oct 20, 1995Paper

AIT-082, a unique purine derivative, enhances nerve growth factor mediated neurite outgrowth from PC12 cells

Neuroscience Letters
P MiddlemissJ W Gysbers

Abstract

AIT-082 is a novel, metabolically stable, derivative of the purine hypoxanthine. Addition of AIT-082 to cultured PC12 cells enhanced significantly nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. These results suggest a cellular mechanism, the enhancement of NGF-action, that might account for the ability of AIT-082 to restore age-induced working memory deficits in mice.

References

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Citations

Jan 6, 2006·Archives of Pharmacal Research·Jung Soo ShinMyung Koo Lee
Apr 12, 2008·Purinergic Signalling·Shucui JiangMichel P Rathbone
Jan 25, 2003·Brain Research·Xiaojun WangMahin D Maines
Jun 14, 2000·Progress in Neurobiology·M P RathboneF Caciagli
May 30, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R CiccarelliP Di Iorio
Jul 5, 2008·Nucleosides, Nucleotides & Nucleic Acids·Michel RathboneShucui Jiang
Jun 13, 2000·Alzheimer Disease and Associated Disorders·M E Jönhagen
Nov 4, 2000·Expert Opinion on Investigational Drugs·H P DeignerR Kinscherf
Apr 3, 2001·Expert Opinion on Investigational Drugs·M Emre, N Qizilbash
Aug 22, 2009·European Journal of Pharmacology·Jinyoung HurSun Yeou Kim
Jul 11, 2002·Mayo Clinic Proceedings·Howard M FillitTim Tully
Nov 10, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Atsutoshi InaYuto Kamei
Nov 10, 2000·Neurologic Clinics·M Grundman, L J Thal
Jul 2, 2005·Expert Opinion on Investigational Drugs·A J GlaskyM P Rathbone
May 19, 2001·Experimental Neurology·P Di IorioR Ciccarelli
Feb 6, 2016·Angewandte Chemie·Benjamin A ChalmersCraig M Williams
Dec 20, 2008·Bioorganic & Medicinal Chemistry Letters·Wanxia TangYoshiyasu Fukuyama
Apr 17, 2002·American Journal of Alzheimer's Disease and Other Dementias·Andrew E BudsonReisa A Sperling
Oct 10, 2006·International Journal of Immunopathology and Pharmacology·F JiangJ Turnbull
Oct 25, 2003·Brain Research·Yoji YoshimiMasahiko Ikekita
Aug 24, 2018·Journal of Medicinal Chemistry·Tristan A ReekieMichael Kassiou

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