'Ajwa' dates (Phoenix dactylifera L.) extract ameliorates isoproterenol-induced cardiomyopathy through downregulation of oxidative, inflammatory and apoptotic molecules in rodent model

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Mohammed Al-YahyaSyed Rafatullah

Abstract

Ajwa, a special variety of Saudi Arabian dates (Phoenix dactylifera L.) is a rich source of nutrients, fibers and bioactive molecules. While previous studies have shown the therapeutic value of dates phytoconstituents in liver and kidney diseases etc., its cardioprotective potential remains elusive. We therefore, investigated the cardioprotective effect of lyophilized Ajwa extract (AJLE) ex vivo as well as in vivo. Ex vivo cardioprotective effect of AJLE was evaluated on DCFH-toxicated cardiomyoblast cells (H9C2). In vivo hemodynamics, cardiac function, serum cardiac enzymes, myocardial antioxidant, inflammatory and apoptotic biomarkers as well as histopathological parameters were studied in IPS-injured Wistar rat heart tissues. AJLE (250 µg/ml) attenuated the cytotoxicity and enhanced the H9C2 proliferation by up to 40%. Oral administration of AJLE (250 and 500 mg/kg.bw) prevented the depletion of endogenous antioxidants (CAT, SOD, NP-SH and NO) and myocyte injury marker enzymes, and inhibited lipid peroxidation (MDA, MPO). Moreover, AJLE downregulated the expressions of proinflammatory cytokines (IL-6, IL-10 and TNFα) and apoptotic markers (caspase-3 and Bax), and upregulated the anti-apototic protein Bcl2. Histological data ...Continue Reading

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Citations

Aug 18, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Alexander N Orekhov
Nov 22, 2018·Food & Function·Luisa F González ArbeláezJosé-Luis Ríos
Mar 21, 2018·Current Drug Discovery Technologies·Ali H El-FarShaker A Mousa
Sep 10, 2016·BMC Complementary and Alternative Medicine·Abdelaaty A ShahatLuc Pieters
Jun 27, 2020·Journal of Food Biochemistry·Atia YounasRana Muhammad Aadil
Jul 17, 2018·Phytotherapy Research : PTR·Prince AllawadhiChandraiah Godugu
Jun 8, 2017·Frontiers in Plant Science·Reem A Al-AlawiYounis Baqi
Jul 5, 2019·BMC Complementary and Alternative Medicine·Mohammad K ParvezAzmat A Khan
Aug 21, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tariq Jamal KhanHassan Mostafa Faidallah
May 1, 2021·International Journal of Molecular Sciences·Yousef A Al-DashtiRobert M Hackman

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