AKI in patients with acute on chronic liver failure is different from acute decompensation of cirrhosis

Hepatology International
Rakhi MaiwallS K Sarin

Abstract

The current definitions of acute kidney injury (AKI) including HRS have been derived from patients with decompensated cirrhosis. No studies have carefully addressed AKI in patients with acute on chronic liver failure (ACLF). We evaluated the prevalence, spectrum, natural history and mortality of AKI at admission and new-onset AKI in hospitalized patients with ACLF and compared the results with patients with acute decompensation of cirrhosis (ADC). Consecutive patients with ACLF (n = 382) and ADC (n = 451) were prospectively studied. Serial renal and liver functions were recorded and correlated with the disease course and outcome. AKI at admission and new onset AKI in the hospital were not different in patients with ACLF and ADC (p > 0.05). However, a significant difference in the spectrum of AKI was noted; functional volume-responsive AKI was more common (p < 0.05) in ADC, while patients with ACLF more frequently had the structural form of AKI (p < 0.05). Moreover, patients with ADC had significantly less AKI progression (p < 0.05) and prolonged duration (p < 0.05), a lower requirement of RRT (p < 0.05) and also less AKI resolution (p < 0.05) compared to ACLF patients. Patients with ACLF (versus ADC) had a significantly higher ...Continue Reading

References

Sep 12, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Mark A PerazellaChirag R Parikh
Nov 13, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guadalupe Garcia-TsaoAntonella Viola
Aug 5, 2010·Gastroenterology·Marta Martín-LlahíPere Ginès
Mar 29, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Justin M BelcherUNKNOWN TRIBE-AKI Consortium
May 29, 2012·Gut·Cynthia D TsienFlorence Wong
Mar 12, 2013·Gastroenterology·Richard MoreauUNKNOWN CANONIC Study Investigators of the EASL–CLIF Consortium
Apr 16, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Justin M BelcherGuadalupe Garcia-Tsao
Jul 3, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Peter FickertMichael Trauner
Jan 1, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Justin M BelcherUNKNOWN TRIBE-AKI Consortium
Jan 11, 2014·World Journal of Gastroenterology : WJG·Zhi-Hong WanShao-Jie Xin
Mar 5, 2014·Virchows Archiv : an International Journal of Pathology·Archana RastogiShiv Kumar Sarin
Mar 29, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jasmohan S BajajUNKNOWN North American Consortium For The Study Of End-Stage Liver Disease (NACSELD)
May 24, 2014·Gastroenterology·Rajiv JalanUNKNOWN World Gastroenterology Organization Working Party
Jul 24, 2015·Hepatology International·Shiv Kumar SarinUNKNOWN APASL ACLF Working Party

❮ Previous
Next ❯

Citations

Oct 17, 2015·Hepatology International·Rakhi MaiwallRichard Moreau
Jun 25, 2016·Critical Care Clinics·Kevin R Regner, Kai Singbartl
Oct 18, 2016·Current Gastroenterology Reports·Shiv Kumar Sarin, Ashok Choudhury
Oct 7, 2017·Hepatology International·Rakhi MaiwallShiv Kumar Sarin
Apr 25, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jasmohan S BajajFlorence Wong
Jan 13, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Bikrant B LalRajeev Khanna
Sep 20, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vinod Arora, Shiv Kumar Sarin
Jun 9, 2018·World Journal of Gastroenterology : WJG·Qun-Qun JiangQin Ning
Aug 5, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vinod AroraShiv Kumar Sarin
Jan 15, 2019·Journal of Clinical and Translational Hepatology·Chitta Ranjan KhatuaShivaram Prasad Singh
Jul 18, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rakhi MaiwallShiv Kumar Sarin
Apr 11, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Rakhi MaiwallUNKNOWN of the APASL ACLF Research Consortium (AARC) working party
Aug 25, 2020·Journal of Clinical and Translational Hepatology·Raseen TariqAshwani K Singal
Aug 27, 2021·Hepatology International·Nidhi NautiyalShiv Kumar Sarin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Larissa Cristina Nascimento de BarrosKleyton de Andrade Bastos
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
Hongling WangTao Han
© 2021 Meta ULC. All rights reserved