AKT as a Therapeutic Target for Cancer

Cancer Research
Mengqiu SongMee-Hyun Lee

Abstract

Many cellular processes in cancer are attributed to kinase signaling networks. V-akt murine thymoma viral oncogene homolog (AKT) plays a major role in the PI3K/AKT signaling pathways. AKT is activated by PI3K or phosphoinositide-dependent kinases (PDK) as well as growth factors, inflammation, and DNA damage. Signal transduction occurs through downstream effectors such as mTOR, glycogen synthase kinase 3 beta (GSK3β), or forkhead box protein O1 (FOXO1). The abnormal overexpression or activation of AKT has been observed in many cancers, including ovarian, lung, and pancreatic cancers, and is associated with increased cancer cell proliferation and survival. Therefore, targeting AKT could provide an important approach for cancer prevention and therapy. In this review, we discuss the rationale for targeting AKT and also provide details regarding synthetic and natural AKT-targeting compounds and their associated studies.

References

Dec 2, 1999·Genes & Development·S R DattaM E Greenberg
Mar 23, 2004·Cancer Biology & Therapy·Alfonso BellacosaLionel Larue
Jan 25, 2005·Bioorganic & Medicinal Chemistry Letters·Craig W LindsleyMark E Duggan
Feb 3, 2005·Bioorganic & Medicinal Chemistry Letters·Zhijian ZhaoCraig W Lindsley
Aug 13, 2005·Advances in Cancer Research·Alfonso BellacosaJoseph Robert Testa
Nov 17, 2005·Journal of the National Cancer Institute·Ho-Young LeeWaun Ki Hong
Nov 17, 2005·Oncogene·Deborah A Altomare, Joseph R Testa
Nov 17, 2005·Oncogene·Jin Q ChengSanto V Nicosia
Dec 13, 2005·Nature Reviews. Drug Discovery·Bryan T HennessyGordon B Mills
May 26, 2006·Nature·Reuben J Shaw, Lewis C Cantley
Feb 9, 2008·Molecular and Cellular Biochemistry·Chen Lu, Amal Shervington
May 2, 2008·Archives of Pharmacal Research·Ju Sin KimDae Keun Kim
May 16, 2008·Bioorganic & Medicinal Chemistry Letters·Mark T BilodeauGeorge D Hartman
Dec 24, 2008·Nature Reviews. Cancer·Jianming ZhangNathanael S Gray
Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ming-Chih CrouthamelRakesh Kumar
Jan 14, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yousif O Al-BazzPauline R M Dobson
May 26, 2009·Nature Chemical Biology·Tatsuya OkuzumiKevan M Shokat
Jul 4, 2009·Cancer Cell·Krishna M VasudevanLevi A Garraway
May 19, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sherry X YangSandra M Swain
Oct 1, 2011·Apoptosis : an International Journal on Programmed Cell Death·Gang ChenYi-Fang Zhao
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Johanna C BendellDonald A Richards
Oct 26, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy A YapAnthony W Tolcher
Mar 1, 2012·Free Radical Biology & Medicine·Shokoofe Noori, Zuhair M Hassan
Jun 21, 2012·Molecular Nutrition & Food Research·Chia-Jui WengGow-Chin Yen
Jul 27, 2012·The Journal of Antimicrobial Chemotherapy·Thomas P C DorloPeter J de Vries
Dec 21, 2012·Oncology Reports·Yasushi SawaiShinji Fushiki
Jan 5, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jie LinKui Lin
Jan 16, 2013·Molecular Cancer Research : MCR·Yanan GuoDavid J Kwiatkowski

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Citations

May 1, 2019·International Journal of Molecular Sciences·Gianmarco PallaviciniFerdinando Di Cunto
Sep 5, 2019·Cells·João M A DelouHelena L Borges
Sep 25, 2019·Cold Spring Harbor Perspectives in Medicine·Taojian TuBangyan L Stiles
Jan 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sean N O'ByrneDavid H Drewry
Jan 23, 2020·Biomolecules·Terezia KiskovaMonika Kassayova
Feb 29, 2020·Cancers·Ferenc GallyasCsaba Szabo
May 21, 2020·The Journal of International Medical Research·Yijun FanLei Zhan
May 31, 2020·Cancer Science·Tatsuo KidoYun-Fai Chris Lau
Jul 14, 2020·International Journal of Radiation Biology·ZhiYuan ChenShunzi Jin
Oct 9, 2019·Nature Medicine·Kathleen E HoulahanPaul C Boutros
Jun 17, 2020·Cancer Cell International·Zhi-Gang SunNan Zhang
Sep 10, 2020·Cancer Cell International·Jiaoduan LiCong Peng
Sep 20, 2020·ESMO Open·Byung Woog Kang, Ian Chau
Aug 15, 2020·Frontiers in Oncology·Mayra Xóchitl Durán-MaldonadoJesús Campos-García
Jul 28, 2020·Journal of Cellular Physiology·Yogendra Prasad KavalappaGanesan Ponesakki
Sep 24, 2020·International Journal of Molecular Sciences·Sun-Young HwangJung-Hyun Shim
Oct 9, 2020·BioMed Research International·Wei WangHaihua Yang
Jan 21, 2021·Oncogenesis·Changhwan YoonSam S Yoon
Sep 2, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Seyede Nazanin ZarneshanLuciano Saso
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tijs MerckaertJan Gettemans
Feb 14, 2021·Journal of Cancer Research and Clinical Oncology·Ísis Salviano Soares de AmorimAndre Luiz Mencalha
Feb 13, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Miaojuan WangXiuping Chen

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