AKT as locus of cancer angiogenic robustness and fragility

Journal of Cellular Physiology
Ziv Radisavljevic

Abstract

Angiogenesis get full robustness in metastatic cancer, relapsed leukemia or lymphoma when complex positive feedback loop signaling systems become integrative. A cancer hypoxic microenvironment generates positive loops inducing formation of the vascular functional shunts. AKT is an upstream angiogenic locus of integrative robustness and fragility activated by the positive loops. AKT controls two downstream nodes the mTOR and NOS in nodal organization of the signaling genes. AKT phosphorylation is regulated by a balance of an oxidant/antioxidant. Targeting AKT locus represents new principle to control integrative angiogenic robustness by the locus chemotherapy.

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Citations

Dec 2, 2015·Oncology Letters·Takamitsu SasakiHiroki Kuniyasu
Oct 24, 2013·International Journal of Cancer. Journal International Du Cancer·Jijia LiJun-Li Luo
Jun 8, 2017·Journal of Cellular Biochemistry·Ziv Radisavljevic
Aug 29, 2014·Journal of Cellular Biochemistry·Ziv Radisavljevic
Nov 14, 2015·Journal of Cellular Biochemistry·Ziv Radisavljevic
Oct 15, 2018·Journal of Cellular Physiology·Ziv Radisavljevic
Apr 26, 2019·Journal of Cellular Biochemistry·Ziv Radisavljevic
May 10, 2020·Neurotoxicity Research·Jinting WangLinlin Zheng
Oct 2, 2014·International Journal of Oncology·Takamitsu Sasaki, Hiroki Kuniyasu

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