Akt signaling and cancer: surviving but not moving on

Cancer Research
Alex Toker, Merav Yoeli-Lerner

Abstract

The frequent deregulation of the phosphoinositide 3-kinase/Akt survival signaling pathway in cancer has prompted significant interest in blocking this pathway to treat cancer. Recently, however, two studies have shown that the Akt isoform Akt1 limits the invasive migration of breast cancer cells. These studies suggest that Akt1 may have a dual role in tumorigenesis, acting not only pro-oncogenically by suppressing apoptosis but also anti-oncogenically by suppressing invasion and metastasis. We discuss the possible implications of these findings for therapeutic development of Akt inhibitors to treat cancer.

References

Sep 5, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D KimJ Chung
Nov 21, 2001·Nature Cell Biology·B P ZhouM C Hung
Jun 25, 2002·Nature Cell Biology·Sebastien JauliacAlex Toker
May 2, 2003·Nature Reviews. Cancer·Peter Friedl, Katarina Wolf
Mar 23, 2005·Current Opinion in Cell Biology·James R Woodgett
Jun 14, 2005·Cancer Cell·Yardena SamuelsVictor E Velculescu
Sep 6, 2005·Developmental Cell·Atsushi EnomotoMasahide Takahashi
Nov 17, 2005·Oncogene·Deborah A Altomare, Joseph R Testa
Dec 21, 2005·The Journal of Cell Biology·Hanna Y IrieJoan S Brugge

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Citations

Oct 24, 2007·Apoptosis : an International Journal on Programmed Cell Death·Uma Sinha-DattaChristophe Nicot
Mar 5, 2009·Apoptosis : an International Journal on Programmed Cell Death·Bhumsoo Kim, Eva L Feldman
Aug 5, 2008·Breast Cancer Research and Treatment·Victoria WargonClaudia Lanari
Jul 27, 2007·Clinical & Experimental Metastasis·Valeria C GrossoniAlejandro J Urtreger
Apr 7, 2009·In Vitro Cellular & Developmental Biology. Animal·Emily HaysNalini Chandar
Oct 23, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Oliver RennerAmancio Carnero
Sep 25, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Luis Paz-AresAmancio Carnero
Oct 24, 2008·Nature Reviews. Molecular Cell Biology·Valter D LongoJan Vijg
Aug 2, 2011·Oncogene·S JohaT Idziorek
Mar 19, 2009·The Journal of Biological Chemistry·Jun XuZhou Songyang
Mar 8, 2007·Carcinogenesis·Carmen Blanco-AparicioAmancio Carnero
Feb 20, 2010·Neuro-oncology·Hideo MureShinji Nagahiro
Jan 6, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Carolina A PontilloAndrea S Randi
Feb 11, 2010·Anti-cancer Drugs·Venkateswaran SubramaniamSerge Jothy
Jan 18, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Abraham JacobLong-Sheng Chang
May 23, 2013·Pancreas·Stéfano M CiriglianoAlejandro J Urtreger
Jun 6, 2009·Pigment Cell & Melanoma Research·Melissa A TranGavin P Robertson
Jan 4, 2008·Breast Cancer Research : BCR·Yuchao GuWengong Yu
Nov 13, 2008·Journal of Lipid Research·Philip W Majerus, John D York
Sep 6, 2007·PloS One·Imad J MatoukEithan Galun
Dec 31, 2008·PloS One·Michela GarofaloGerolama Condorelli
Feb 14, 2014·PloS One·Seungwon Yang, Hyun-Man Kim
Mar 26, 2014·PloS One·Aditi MukherjeePeter Rotwein
Apr 12, 2014·PloS One·Nicolle M Linnerth-PetrikSarah K Wootton
Aug 24, 2013·Marine Drugs·Hye-Jin BooHee-Kyoung Kang
Dec 7, 2013·Environmental Toxicology and Pharmacology·Dong Yeok ShinYung Hyun Choi

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