Akt versus p53 in a network of oncogenes and tumor suppressor genes regulating cell survival and death.

Biophysical Journal
Keng Boon Wee, Baltazar D Aguda

Abstract

The tumor suppressor protein, p53, and the oncoprotein, Akt, are involved in a cross talk that could be at the core of a cell's control machinery for switching between survival and death. This cross talk is a combination of reciprocally antagonistic pathways emanating from p53 and Akt, and also involves another tumor suppressor gene, PTEN, and another oncogene, Mdm2; such a connected network of cancer-relevant genes must be significant and demands a critical study. The p53-Akt network is shown in this report to possess the potential to exhibit bistability, a phenomenon in which two stable steady states of the system coexist for a fixed set of control parameter values. A hierarchy of qualitative networks and abstract kinetic models are analyzed and simulated on a computer to demonstrate the robustness of the bistable behavior, which, as argued in this study, is a likely candidate mechanism for a cellular survival-death switch. The analysis applies to cells that are neither p53-null nor Akt-null. The models presented here offer experimental predictions on the identity of control parameters of apoptotic thresholds and on network perturbations (including DNA damage and Akt inhibition) that are sufficient to generate switching betwe...Continue Reading

References

Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·L C Cantley, B G Neel
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·M M GeorgescuH Hanafusa
Dec 2, 1999·Genes & Development·S R DattaM E Greenberg
Jun 24, 2000·Molecular and Cellular Biology·F VazquezW R Sellers
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·R Lev Bar-OrM Oren
Sep 8, 2001·Molecular Cell·V StambolicT W Mak
Dec 1, 2001·The Journal of Biological Chemistry·Lindsey D MayoDavid B Donner
Mar 8, 2002·Cellular Signalling·Karleen M Nicholson, Neil G Anderson
Apr 18, 2002·Genes & Development·Bhuvanesh SinghArchontoula Stoffel
Apr 19, 2002·Carcinogenesis·Dania Alarcon-Vargas, Ze'ev Ronai
Sep 10, 2002·Trends in Biochemical Sciences·Lindsey D Mayo, David B Donner
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Ahmad R SedaghatMichael J Quon
Mar 22, 2003·Current Opinion in Cell Biology·John J TysonBela Novak
Apr 30, 2003·Cell Death and Differentiation·M Oren
Sep 16, 2003·Journal of Cell Science·Susan HauptYgal Haupt
Sep 25, 2003·Cell Cycle·Baltazar D Aguda, Christopher K Algar
Dec 10, 2003·Oncogene·Thomas F FrankeChizuru Sugimoto
Jan 20, 2004·Nature Genetics·Galit LahavUri Alon
Apr 14, 2004·The Journal of Biological Chemistry·Venugopalan D NairStuart C Sealfon
Jun 15, 2004·The Biochemical Journal·Nick R Leslie, C Peter Downes
Jun 23, 2004·The Journal of Biological Chemistry·Thomas EissingPeter Scheurich
Sep 15, 2004·The Journal of Cell Biology·M BenteleR Eils
Nov 19, 2004·Nature·Scott W LoweGerard Evan
Dec 21, 2004·Development, Growth & Differentiation·Dongru QiuMasaru Tomita
Feb 22, 2005·Journal of Theoretical Biology·Jörg W Stucki, Hans-Uwe Simon
Feb 24, 2005·Cell Cycle·Andrea CilibertoJohn J Tyson
Apr 20, 2005·Oncogene·Sandra L Harris, Arnold J Levine
Sep 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lan MaGustavo A Stolovitzky

❮ Previous
Next ❯

Citations

May 15, 2012·Applied Biochemistry and Biotechnology·Nan WangJin-ku Bao
Nov 18, 2011·International Journal of Hematology·Huifang HuangYong Wu
May 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Peng ZhangWei Wang
Jun 24, 2009·BMC Bioinformatics·Tingzhe SunPingping Shen
Dec 9, 2010·BMC Bioinformatics·Haijun GongEdmund M Clarke
Oct 3, 2007·PLoS Computational Biology·Baltazar D Aguda, Andrew B Goryachev
Feb 7, 2009·PloS One·Keng Boon WeeBaltazar D Aguda
Jun 10, 2010·PloS One·Ivan Martínez-ForeroPablo Villoslada
Jan 25, 2011·Journal of Experimental Stroke & Translational Medicine·Donald J Degracia
Feb 4, 2014·FEBS Letters·Tingzhe Sun, Jun Cui
Sep 23, 2008·Current Opinion in Biotechnology·Anushree ChatterjeeWei-Shou Hu
Jun 26, 2008·Journal of Theoretical Biology·Krzysztof PuszyńskiTomasz Lipniacki
Mar 21, 2007·Immunological Reviews·Jaroslav StarkAndrew J T George
Apr 12, 2016·Frontiers in Oncology·Zhan YuMarco Durante
Jun 9, 2012·Biophysical Journal·Xiao-Peng ZhangWei Wang
May 4, 2016·Mathematical Biosciences·Fajar Adi-Kusumo, Ario Wiraya
Mar 2, 2016·PLoS Computational Biology·Beata HatTomasz Lipniacki
May 10, 2017·Proceedings of the National Academy of Sciences of the United States of America·Xinyu TianWei Wang
Sep 9, 2015·Scientific Reports·Chun-Hong ZhouWei Wang
Nov 11, 2018·FEBS Letters·Ping WangWei Wang
Sep 14, 2010·Physical Biology·Tingzhe SunPingping Shen
Feb 20, 2020·International Journal of Molecular Sciences·Chunyan GaoFang Yan
Apr 14, 2017·Acta Biochimica Et Biophysica Sinica·Jiaqi LiuLinxi Chen
Sep 21, 2019·IET Systems Biology·Chunyan GaoHaihong Liu
Jan 25, 2020·Molecular Medicine Reports·Rui-Ying WangXiao-Bing Shen
Sep 5, 2018·Cell Communication and Signaling : CCS·Yajie WangNing Wei
Jan 16, 2021·The Journal of Chemical Physics·Leijun YeChunhe Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Related Papers

Journal of Theoretical Biology
Krzysztof PuszyńskiTomasz Lipniacki
Proceedings of the National Academy of Sciences of the United States of America
Xiao-Peng ZhangWei Wang
© 2022 Meta ULC. All rights reserved