Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development.

The International Journal of Developmental Biology
Lindsey N KentMichael J Soares

Abstract

Phenotypic characterization of Akt1 and Igf2 null mice has revealed roles for each in the regulation of placentation, and fetal and postnatal growth. Insulin-like growth factor 2 (IGF2) is encoded by the Igf2 gene and influences cellular function, at least in part, through activation of an intracellular serine/threonine kinase called AKT1. Akt1 and Igf2 null mice were originally characterized on inbred and mixed genetic backgrounds, prohibiting direct comparisons of their phenotypes. The impact of loss of AKT1 or IGF2 on placental, fetal, and postnatal function were examined following transfer of Akt1 and Igf2 null mutations to an outbred CD1 genetic background. Disruption of IGF2 did not affect AKT expression or activation. Both Akt1-/- and Igf2-/- mice exhibited decreased placental weight, fetal weight and viability. Deregulation of placental growth was similar in Akt1 and Igf2 nulls; however, disruption of Igf2 had a more severe impact on prenatal survival and postnatal growth. Placental structure, including organization of junctional and labyrinth zones and development of the interstitial, invasive, trophoblast lineage, were similar in mutant and wild-type mice. Akt1 and Igf2 null mutations affected postnatal growth. The re...Continue Reading

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Citations

Oct 12, 2012·Veterinary Research Communications·Ajai K TripathiChaitanya G Joshi
Nov 12, 2015·The Journal of Obstetrics and Gynaecology Research·Huiyue ChenWeiwei Song
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Aug 27, 2021·Cellular and Molecular Gastroenterology and Hepatology·Joonyong LeeGuoli Dai
Nov 7, 2021·European Journal of Clinical Nutrition·P KochharA Mukhopadhyay

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