AKT1-dependent activation of NF-kappaB by the L protein of parainfluenza virus 5.

Journal of Virology
Priya LuthraBiao He

Abstract

Innate immunity plays a critical role in the control of viral infections. The induction of innate immune responses requires activation of transcription factors. In particular, NF-kappaB plays an essential role in activating the expression of cytokines involved in innate immunity such as beta interferon (IFN-beta) and interleukin-6 (IL-6). However, the mechanisms by which viruses activate NF-kappaB are poorly defined. Infection by parainfluenza virus 5 (PIV5), a prototypical member of the Paramyxoviridae family of Mononegavirales, has been shown to activate the expression of IFN-beta and IL-6. To examine how PIV5 induces this expression, we have examined the activation of NF-kappaB by PIV5 proteins. We have found that expression of PIV5 L protein alone is sufficient to activate NF-kappaB. The L protein of PIV5, the catalytic component of the viral RNA-dependent RNA polymerase, contains six domains that are conserved among all negative-stranded nonsegmented RNA viruses. We have mapped the region that activates NF-kappaB to the second domain, which is thought to be involved in RNA synthesis. The activation of NF-kappaB by L requires AKT1, a serine/threonine kinase, since AKT1 small interfering RNA, an AKT inhibitor as well as a do...Continue Reading

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Citations

Feb 16, 2011·Journal of Medicinal Chemistry·Qi SunBlake R Peterson
Feb 19, 2010·Journal of Virology·Nishi R SharmaDebi P Sarkar
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Priya LuthraBiao He
Oct 28, 2017·Molecular Biology of the Cell·Sunandini ChandraDebi P Sarkar
Sep 27, 2013·Journal of Virology·Zhuo LiBiao He
Sep 13, 2012·Journal of Viral Hepatitis·V WilliamsE Gordien
May 23, 2013·Immunology·Yan ZhangGuangwei Liu
Apr 17, 2020·Journal of Virology·Kelsey BriggsBiao He
Aug 3, 2020·Archives of Virology·Javier BlancoIsabel Muñoz-Barroso

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