Abstract
It is unclear whether AL amyloidoma of the skin/subcutis represents a distinct entity, an indolent precursor of systemic amyloidosis, or a manifestation of cutaneous marginal zone lymphoma (cMZL). We collected 10 cases of cutaneous AL amyloidoma in order to better characterize the clinicopathologic features of this elusive entity (M:F=4:6; median age: 62.5 y, range: 31 to 82 y). Nine patients had a solitary nodule or plaque on the lower extremity (n=7), upper extremity (n=1), or chin (n=1). One patient had an AL amyloidoma on the right thigh and a second lesion on the right arm showing histopathologic features of cMZL without amyloid deposits. Clinical investigations excluded relevant systemic disease in all cases. Microscopically, dermal/subcutaneous deposits of amyloid were associated with sparse to moderate perivascular infiltrates of lymphocytes and monotypic plasma cells (7 with kappa and 3 with lambda light chain restriction). The plasma cells expressed CD56 in one of 9 studied cases. One case was characterized by a t(14;18)(q32;q21)/IGH-MALT1 translocation. Follow-up was available in 8 cases. All remain systemically well after a median time of 86.5 months (range: 40 to 144 mo). Local recurrence of disease was observed in...Continue Reading
References
Aug 1, 1993·American Journal of Clinical Pathology·J KrishnanG Frizzera
Jan 23, 1999·American Journal of Clinical Pathology·J W HussongG Frizzera
Jul 17, 2001·The British Journal of Dermatology·A Woollons, M M Black
Jul 31, 2001·Journal of Clinical Pathology·J K LimM A Gertz
Oct 31, 2002·Blood·Berthold StreubelAndreas Chott
Dec 25, 2002·Journal of Clinical Pathology·M KambouchnerA Martin
Sep 17, 2003·Archives of Dermatology·Alison O MoonJohn S Walsh
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
May 16, 2006·Annals of the Rheumatic Diseases·S R Pillemer
Apr 7, 2007·The American Journal of Dermatopathology·Sylvia PasternakNoreen Walsh
Jun 20, 2007·Blood·Ernesto Pérez-PersonaJesús F San Miguel
Jun 26, 2008·Arthritis and Rheumatism·Jiska M MeijerBouke P C Hazenberg
May 29, 2010·Chinese Journal of Cancer·Hai-Yan ZhangJian-Xin Wang
Sep 28, 2010·American Journal of Hematology·David TelioVishal Kukreti
Mar 19, 2011·International Journal of Dermatology·Michael KendlerTino Wetzig
Dec 8, 2011·Anais Brasileiros De Dermatologia·Januário de Souza JúniorCesare Massone
Dec 20, 2011·American Journal of Clinical Pathology·Russell J H RyanJudith A Ferry
Feb 18, 2012·Upsala Journal of Medical Sciences·Per Westermark
Jan 4, 2013·The American Journal of Surgical Pathology·Karen L GroggAhmet Dogan
Dec 22, 2015·The Lancet. Haematology·Shameem MahmoodAshutosh D Wechalekar
Jan 7, 2016·Blood Reviews·Siobhan V Glavey, Nelson Leung
Citations
Feb 3, 2018·Medicine·Linge SunShengyun Liu
Aug 4, 2018·Journal of Cutaneous Pathology·Aria ShakeriAlejandro A Gru
Feb 26, 2019·The British Journal of Dermatology·A DangienA de Masson
Mar 7, 2019·The American Journal of Dermatopathology·Stefan UeberdiekChristina Mitteldorf
May 17, 2019·Journal of Cutaneous Pathology·Noreen M WalshLorenzo Cerroni
Mar 7, 2019·The American Journal of Dermatopathology·Cynthia M MagroShabnam Momtahen
Oct 22, 2019·The American Journal of Dermatopathology·Andrea SagginiCarlo Cota
Sep 2, 2020·Journal of Cutaneous Pathology·Alexandra C HristovUma Sundram
Dec 13, 2019·SAGE Open Medical Case Reports·Carolina FernandesMylène Veilleux
Nov 30, 2019·Virchows Archiv : an International Journal of Pathology·Ilske OschliesJohn R Goodlad
Jul 25, 2020·Skeletal Radiology·Sohil S DesaiMotasem Al Maaieh
Jan 27, 2019·Virchows Archiv : an International Journal of Pathology·Christiane Stuhlmann-LaeiszChristoph Röcken
Jul 1, 2020·American Journal of Hematology·Marco BassetStefan Schönland
Mar 18, 2021·Clinical, Cosmetic and Investigational Dermatology·Andrea RonchiRenato Franco
Jan 6, 2021·The American Journal of Surgical Pathology·Ana Cristina VargasFiona M Maclean
Oct 12, 2018·JAAD Case Reports·Julia L AccettaMihai Merzianu
Jul 8, 2021·The American Journal of Dermatopathology·Sammie J RobertsM Yadira Hurley
Dec 28, 2021·Histopathology·Ilske Oschlies, Ulrike Wehkamp