AL amyloidosis with IgD-lambda monoclonal gammopathy and lambda-type Bence-Jones protein: successful treatment by autologous stem cell transplantation.

Clinical and Experimental Nephrology
Chanhyok Sakurai-ChinKenichi Oohashi

Abstract

A 45-year-old Japanese woman had been diagnosed with monoclonal gammopathy of undetermined significance (MGUS) featuring urinary Bence-Jones protein of the lambda type (BJP-lambda) for 11 years. She then developed eyelid purpura, dyspnea, and flank pain. Abdominal CT scans revealed renal infarction. Biopsy of the kidney, heart, jejunum, and skin demonstrated amyloid deposits in the vessel walls, but not in the glomeruli. She was diagnosed as having AL amyloidosis with IgD-lambda monoclonal gammopathy and BJP-lambda. Autologous stem cell transplantation (SCT) was done after chemotherapy with vincristine, daunorubicin, dexamethasone (VAD), and high-dose melphalan (HDM). This reduced the IgD level from 156 to 0.1 mg/dL, along with the disappearance of BJP, despite cerebral infarction during chemotherapy. We recommend SCT for patients with IgD-associated AL amyloidosis.

References

Jul 1, 1975·Medicine·R A Kyle, E D Bayrd
Aug 1, 1991·Cancer·M L O'ConnorH B Muss
Oct 1, 1994·British Journal of Haematology·J Bladé, R A Kyle
Nov 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J BladéR A Kyle
Jan 1, 1996·European Radiology·M AriasF Vega
Feb 1, 1997·International Journal of Hematology·T KinoshitaT Hotta
Sep 26, 1997·The New England Journal of Medicine·R H FalkM Skinner
Feb 22, 2002·The New England Journal of Medicine·Robert A KyleL Joseph Melton
Feb 1, 2005·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Takahisa GonoShu-ichi Ikeda
Oct 1, 2005·Scandinavian Journal of Rheumatology·P HausfaterJ C Piette
Aug 30, 2006·British Journal of Haematology·Robert A Kyle, S Vincent Rajkumar
Nov 7, 2006·Revue neurologique·A SauxM Pagès
Sep 12, 2007·Neurology·Alexander Y ZubkovEelco F M Wijdicks
Sep 15, 2007·The New England Journal of Medicine·Arnaud JaccardUNKNOWN Myélome Autogreffe (MAG) and Intergroupe Francophone du Myélome (IFM) Intergroup
Sep 3, 2008·Cellular & Molecular Immunology·Hao WangXiantao Kong

❮ Previous
Next ❯

Citations

Nov 9, 2011·Blood·Morie A GertzRobert A Kyle
Sep 2, 2016·Internal Medicine·Toshiharu UenoYoshifumi Ubara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.