Alachlor Use and Cancer Incidence in the Agricultural Health Study: An Updated Analysis

Journal of the National Cancer Institute
Catherine C LerroLaura E Beane Freeman

Abstract

The herbicide alachlor has been widely used in US agriculture since its introduction in 1969. Experimental animal studies show that alachlor causes tumors in vivo; however, few epidemiologic studies have examined associations with human cancer risk. We evaluated alachlor use and cancer incidence in the Agricultural Health Study, updating an earlier analysis that suggested associations with lymphohematopoietic cancers with an additional 540 142 person-years of follow-up and 5113 cancer cases. Pesticide applicators in Iowa and North Carolina reported lifetime alachlor use at enrollment (1993-1997) and follow-up (1999-2005). Exposure was characterized by cumulative intensity-weighted days. We estimated relative risks (RRs) and 95% confidence intervals (CIs) using Poisson regression for incident cancers from enrollment through 2012(NC)/2013(IA). Models adjusted for age, tobacco, alcohol, and other pesticides. All statistical tests are two-sided. Among 49 685 applicators, 25 640 (51.6%) used alachlor, with 3534 alachlor-exposed cancers. The relative risks of laryngeal cancer (nexposed = 34) increased in the second (RR = 4.68, 95% CI = 1.95 to 11.23), third (RR = 6.04, 95% CI = 2.44 to 14.99), and fourth quartiles (RR = 7.10, 95% CI ...Continue Reading

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Citations

May 2, 2020·International Journal of Epidemiology·Catherine C LerroLaura E Beane Freeman
Jan 22, 2020·Current Environmental Health Reports·Cynthia L CurlLuke Montrose
Feb 26, 2019·Cancer Causes & Control : CCC·Catherine C LerroLaura E Beane Freeman
Feb 20, 2021·Environmental Research·Michael K OdutolaClaire M Vajdic

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