Alamandine attenuates hypertension and cardiac hypertrophy in hypertensive rats

Amino Acids
Chi LiuXiang-Qing Kong

Abstract

Oral administration of the peptide alamandine has antihypertensive and anti-fibrotic effects in rats. This work aimed to determine whether subcutaneous alamandine injection would attenuate hypertension and cardiac hypertrophy, and improve the function of a major target of hypertension-related damage, the left ventricle (LV), in spontaneously hypertensive rats (SHRs). This was examined in vivo in SHRs and normotensive rats subjected to 6-week subcutaneous infusion of alamandine or saline control, and in vitro in H9C2-derived and primary neonatal rat cardiomyocytes treated with angiotensin (Ang) II to model cardiac hypertrophy. Tail artery blood pressure measurement and transthoracic echocardiography showed that hypertension and impaired LV function in SHRs were ameliorated upon alamandine infusion. Alamandine administration also decreased the mass gains of heart and lung in SHRs, suppressed cardiomyocyte cross-sectional area expansion, and inhibited the mRNA levels of atrial natriuretic peptide and brain natriuretic peptide. The expression of alamandine receptor Mas-related G protein-coupled receptor, member D was increased in SHR hearts and in cardiomyocytes treated with Ang II. Alamandine inhibited the increases of protein kin...Continue Reading

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Citations

Jan 22, 2019·Nature Reviews. Nephrology·Xiaoliang Wang, Joseph I Shapiro
Feb 10, 2019·Clinical Science·Fernando Pedro de Souza-NetoRafaela Fernandes da Silva
Apr 13, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Nelson EscobalesSabzali Javadov
Aug 21, 2019·Nature Reviews. Cardiology·Maria Paz OcaranzaSergio Lavandero
Sep 12, 2019·Current Hypertension Reports·Omar AzzamMarkus P Schlaich
Mar 4, 2019·Current Hypertension Reports·Merrill H StewartHector O Ventura
Jan 9, 2020·American Journal of Physiology. Cell Physiology·Itamar Couto Guedes JesusSilvia Guatimosim
Jan 23, 2020·Journal of Clinical Medicine·Amalie L PovlsenMarcus Krüger
Oct 31, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Mário Morais SilvaRafaela Fernandes da Silva
Jan 27, 2021·The Journal of Pharmacology and Experimental Therapeutics·Sana Khajehpour, Ali Aghazadeh-Habashi
Jan 5, 2021·Journal of Cardiovascular Pharmacology·Danyelle S MiottoSandra L Amaral
May 30, 2021·BMC Pharmacology & Toxicology·Ava Soltani HekmatKazem Javanmardi
Jul 11, 2021·The Journal of Pharmacy and Pharmacology·Jue ZhuKe Jiang

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Methods Mentioned

BETA
reverse-transcription PCR

Software Mentioned

Pro Plus
Image
GraphPad Prism
GraphPad
Zeiss

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