Alanine aminotransferase and gamma-glutamyl transferase are associated with the metabolic syndrome but not with angiographically determined coronary atherosclerosis

Clinica Chimica Acta; International Journal of Clinical Chemistry
Christoph H SaelyHeinz Drexel

Abstract

Recently, elevated liver enzymes have attracted great interest as potential novel markers of cardiovascular risk. Their association with angiographically determined coronary artery disease (CAD) is unknown. We enrolled 1000 consecutive patients undergoing coronary angiography for the evaluation of suspected or established stable CAD. The metabolic syndrome (MetS) was defined according to ATP-III criteria; significant CAD was diagnosed in the presence of coronary stenoses with lumen narrowing >or=50%. Serum alanine aminotransferase (ALT), the ALT/aspartate aminotransferase (AST) ratio, and serum gamma-glutamyl transferase (GGT) were significantly higher in patients with the MetS than in subjects without the MetS (34+/-21 vs. 29+/-20 U/l; p<0.001, 1.16+/-0.39 vs. 1.00+/-0.36 U/l, p<0.001; and 53+/-88 vs. 43+/-57 U/l, p=0.001, respectively) but were similar in patients with significant CAD as in those who did not have significant CAD at angiography (p=0.592; p=0.731, and p=0.716, respectively). Analysis of covariance after multivariate adjustment including alcohol consumption confirmed that ALT, ALT/AST ratio, and GGT were significantly and independently associated with the MetS but not with significant CAD. ALT, the ALT/AST ratio...Continue Reading

References

Apr 27, 2000·The New England Journal of Medicine·D S Pratt, M M Kaplan
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jul 27, 2001·Diabetes·G MarchesiniN Melchionda
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
Dec 16, 2004·The Journal of Clinical Endocrinology and Metabolism·F AngelicoF Violi
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Aug 11, 2005·The Journal of Clinical Endocrinology and Metabolism·Christoph H SaelyHeinz Drexel
Sep 28, 2005·Circulation·Elfriede RuttmannUNKNOWN Vorarlberg Health Monitoring and Promotion Program Study Group
Dec 16, 2005·The American Journal of the Medical Sciences·Brent A Neuschwander-Tetri
Jan 27, 2006·European Journal of Clinical Investigation·C H SaelyH Drexel
Dec 1, 2006·The New England Journal of Medicine·Renata BelfortKenneth Cusi
Jan 18, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·G Targher
Jun 28, 2007·The Journal of Clinical Endocrinology and Metabolism·Anna KotronenHannele Yki-Järvinen
Aug 19, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Peyman AdibiMasood Mohseni

❮ Previous
Next ❯

Citations

Nov 26, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S BeerH Drexel
Mar 26, 2011·Journal of Physiology and Biochemistry·Tiago Gomes AraújoVera Lúcia de Menezes Lima
Feb 7, 2013·Vascular Health and Risk Management·Jana E Montgomery, Jeremiah R Brown
Jan 26, 2016·Metabolic Syndrome and Related Disorders·Harry Robberecht, Nina Hermans
Apr 2, 2011·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Saira ShabbirBashir M Matata
Jul 18, 2012·Journal of Cardiovascular Medicine·Lu-Qin BianYoon-Ho Choi
Apr 16, 2015·European Journal of Gastroenterology & Hepatology·Martin JaničkoUNKNOWN HepaMeta Study Group
Jul 9, 2014·European Journal of Gastroenterology & Hepatology·Zhongli WangEnyin Lai
Sep 27, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Robin P F DullaartRindert de Vries

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.