PMID: 7021995Jul 15, 1981Paper

Alanine as a nitrogen sparing and gluconeogenetic substrate in the postoperative state (author's transl)

Klinische Wochenschrift
J FunovicsA Fritsch

Abstract

An alanine infusion (90 mg/kg/h) for eight hours was administered to seven patients after cholecystectomy in order to investigate the influence of elevated plasma alanine levels on the postoperative metabolism. The following metabolites and hormone concentrations were analysed in plasma: glucose, urea, free fatty acids, ketone bodies, amino acids, insulin and glucagon. Compared to the pre-infusion values on the 1. postoperative day after an overnight fasting, the following changes were monitored. The plasma glucose concentrations reached a maximum after four hours of infusion (p less than 0.05). Of the amino acids, significant elevated levels were found for alanine (300%, p less than 0.001), glutamine (36%, p less than 0.05), and alpha-aminobutyrate (61%, p less than 0.01). The free fatty acids and ketone bodies concentrations decreased immediately after the onset of the infusion of alanine (p less than 0.05), the increased again during the last four hours of infusion. The secretion of insulin and also the secretion of glucagon were stimulated by the increased alanine levels. The stimulation of insulin reached a maximum after only five minutes, but the glucagon levels increased continuously until the end of the infusion. During...Continue Reading

References

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Citations

May 11, 2006·American Journal of Physiology. Endocrinology and Metabolism·Petra G BoelensNicolaas E Deutz
Nov 23, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Erich Roth, Wilfred Druml
Dec 9, 1997·The British Journal of Nutrition·K Holtenius, P Holtenius

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