Alantolactone exhibited anti-herpes simplex virus 1 (HSV-1) action in vitro

Bioscience Trends
Caidan RezengPengcuo Jiumei

Abstract

The aim of this study was to determine the inhibitory action of alantolactone, a gradient of traditional Chinese medicine Inulae Radix (Tu-Mu-Xiang), on herpes simplex virus 1 (HSV-1). African green monkey kidney cells (Vero cells) were infected with HSV-1 and the protective effects of alantolactone on Vero cells were examined. At concentrations of 10(-6), 10(-7), and 10(-8) g/mL, alantolactone did not have a marked harmful effect on the viability of Vero cells according to an MTT assay. Based on the cytopathic effect (CPE) and MTT assays, alantolactone at these concentrations exhibited antiviral action and protected cells from being damaged by HSV-1. Results indicated that alantolactone had potent anti-HSV-1 action and provided evidence for use of Inulae Radix in the treatment of HSV-1 infection.

References

Jun 2, 2012·International Journal of Nanomedicine·Xianting DingChih-Ming Ho
Jan 16, 2014·Drug Discoveries & Therapeutics·T IchinoseN Kobayashi
Aug 28, 2014·Infectious Disorders Drug Targets·Jun HuangYonggui Song
Mar 22, 2015·The Journal of General Virology·Peter G E KennedyRandall J Cohrs
Dec 10, 2015·Journal of Intercultural Ethnopharmacology·Hacı Kemal ErdemliOmer Akyol

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Citations

Sep 28, 2017·The Journal of Antibiotics·Yuezhou WangXianming Deng
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karin Lunz, Iris Stappen
Oct 9, 2021·Chemical Biology & Drug Design·Xin LiuLongfei Yang

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