PMID: 18203901Jan 22, 2008Paper

Alanyl-glutamine consumption modifies the suppressive effect of L-asparaginase on lymphocyte populations in mice

The Journal of Nutrition
Piyawan BunpoTracy G Anthony

Abstract

Asparaginase (Elspar) is used in the treatment of acute lymphoblastic leukemia. It depletes plasma asparagine and glutamine, killing leukemic lymphoblasts but also causing immunosuppression. The objective of this work was to assess whether supplementing the diet with glutamine modifies the effect of asparaginase on normal lymphocyte populations in the spleen, thymus, and bone marrow. Mice consuming water ad libitum with or without alanyl-glutamine dipeptide (AlaGln; 0.05 mol/L) were injected once daily with 0 or 3 international units/g body weight Escherichia coli L-asparaginase for 7 d. Tissue expression of specific immune cell surface markers was analyzed by flow cytometry. Asparaginase reduced B220+ and sIgM+ cells in the bone marrow (P < 0.05) and diminished total cell numbers in thymus (-42%) and spleen (-53%) (P < 0.05). In thymus, asparaginase depleted double positive (CD4+ CD8+) and single positive (CD4+ CD8-, CD4-CD8+) thymocytes by over 40% (P < 0.05). In spleen, asparaginase reduced CD19+ B cells to 33% of controls and substantially depleted the CD4+ and CD8+ T cell populations. CD11b-expressing leukocytes were reduced by 50% (P < 0.05). Consumption of AlaGln did not lessen the effects of asparaginase in bone marrow ...Continue Reading

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Citations

Dec 8, 2017·Biomolecules & Therapeutics·Yeon-Kyung Choi, Keun-Gyu Park
Nov 26, 2009·European Journal of Nutrition·Katharina S KuhnPeter Stehle
Oct 17, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Chen ZhengYue Zhou
Sep 21, 2013·Future Medicinal Chemistry·Michael J LukeyRichard A Cerione
Dec 17, 2011·Journal of Nutrition and Metabolism·Elise Mok, Régis Hankard
Sep 5, 2013·American Journal of Physiology. Endocrinology and Metabolism·Gabriel J WilsonTracy G Anthony
Apr 16, 2013·Cancer Research·Ehsan A EhsanipourSteven D Mittelman
Jul 6, 2015·Journal of Molecular Biology·Andriy AnishkinSusan B Rempe

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