PMID: 2122821Nov 1, 1990Paper

Alanyl-glutamine counteracts the depletion of free glutamine and the postoperative decline in protein synthesis in skeletal muscle

Annals of Surgery
F HammarqvistE Vinnars

Abstract

Skeletal muscle protein and amino acid metabolism change after surgical trauma during a period characterized by skeletal muscle protein catabolism. Available total parenteral nutrition (TPN) not containing glutamine does not prevent these changes, while TPN enriched with glutamine has been shown to have beneficial effects on postoperative skeletal muscle protein metabolism. Glutamine, in the form of a dipeptide, alanyl-glutamine, was added to TPN. Patients undergoing elective cholecystectomy were given postoperative TPN. Two groups received isocaloric and isonitrogenous conventional TPN, one group with (n = 8) and the other without an addition of alanyl-glutamine (n = 8). Skeletal muscle protein metabolism was studied in muscle biopsy specimens from which the muscle free amino acid pattern and the concentration and size distribution of ribosomes, serving as a measure of protein synthesis, were determined. In the control group, muscle free glutamine decreased by 38.8% +/- 6.6% and the polyribosome concentration per mg of DNA decreased by 21% +/- 5.2% after operation. In the group given TPN supplemented with alanyl-glutamine, these two parameters of muscle protein and amino acid metabolism did not change significantly. Compared t...Continue Reading

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Citations

Dec 3, 1999·Amino Acids·P C Calder, P Yaqoob
Feb 20, 2008·Amino Acids·M FuchsJ Mühling
Jul 1, 1997·Nutrition·P Yaqoob, P C Calder
Jul 1, 1997·Nutrition·P FürstP Stehle
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Sep 6, 2012·Annals of Nutrition & Metabolism·Lin JinZhanggang Xue
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Jan 1, 1991·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J Wernerman
Feb 1, 1993·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·P Fürst
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Jun 13, 1998·The Journal of Nutrition·P Fürst

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