Alanyl-glutamine dipeptide-supplemented parenteral nutrition improves intestinal metabolism and prevents increased permeability in rats

Annals of Surgery
S M HaqueA Okada

Abstract

The authors determined the effects of alanyl-glutamine-supplemented total parenteral nutrition (TPN) on mucosal metabolism, integrity, and permeability of the small intestine in rats. Male Sprague-Dawley rats were randomized to receive TPN supplemented with a conventional amino acids mixture (STD group) or the same solution supplemented with alanyl-glutamine; both solutions were isocaloric and isonitrogenous. On the seventh day of TPN, D-xylose and fluorescein isothiocyanate (FITC)-dextran were administered orally. One hour later, superior mesenteric vein (SMV) D-xylose and plasma FITC-dextran concentration were measured. Intestinal blood flow and calculated intestinal substrates flux were measured with ultrasonic transit time flowmetery. Plasma FITC-dextran increased significantly in the STD group. Intestinal blood flow and SMV D-xylose concentration did not differ between the groups. Mucosa weight, villus height, mucosal wall thickness, mucosal protein, and DNA and RNA content in jejunal mucosa were significantly increased in the alanyl-glutamine group. Jejunal mucosal glutaminase activity and net intestinal uptake of glutamine (glutamine flux) were significantly higher in the alanyl-glutamine group as compared with the STD g...Continue Reading

References

Nov 24, 1979·Lancet·I S MenziesB Creamer
May 1, 1978·The Journal of Pediatrics·J P ButsA Bonin
Aug 1, 1977·Archives of Biochemistry and Biophysics·L M Pinkus, H G Windmueller
Jun 1, 1976·Clinical Biochemistry·J T Hindmarsh
May 1, 1992·Clinical Science·S Travis, I Menzies
Mar 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·H TamadaA Okada
Jan 1, 1991·Annual Review of Nutrition·W W Souba
Jan 1, 1991·American Journal of Surgery·J C Thompson
Aug 1, 1989·Scandinavian Journal of Gastroenterology·S PurandareS Bengmark
Jul 1, 1989·Nutrition Reviews·C W Lo, W A Walker
Nov 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·S T O'DwyerD W Wilmore
Aug 1, 1989·Metabolism: Clinical and Experimental·P FürstP Stehle
May 1, 1988·The Journal of Surgical Research·J P Grant, P J Snyder
Jan 1, 1987·Gut·S R Bloom
Sep 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·W W SoubaD W Wilmore
Jan 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·W W SoubaD W Wilmore
Jul 1, 1974·The Journal of Surgical Research·I L CameronE Urban
Apr 1, 1969·The American Journal of Physiology·M L Katz, E N Bergman
Jul 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·Y IiboshiA Okada
May 29, 1993·Lancet·R R van der HulstP B Soeters

❮ Previous
Next ❯

Citations

Jul 3, 1998·Gastroenterology Clinics of North America·R D Rothstein, J L Rombeau
Dec 10, 1998·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·K AriiY Kokuba
May 4, 1999·The International Journal of Biochemistry & Cell Biology·R McCauleyJ C Hall
Jun 1, 1997·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·M BaşoğluD Oren
Jan 18, 2008·World Journal of Gastroenterology : WJG·Arda DemirkanMehmet Melli
Jan 18, 2005·The Journal of Surgical Research·Masafumi WasaMasahiro Fukuzawa
Jul 31, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Keizo FukushimaNobuyuki Sugioka
Aug 14, 2002·World Journal of Gastroenterology : WJG·Yan Gu, Zhao-Han Wu
Apr 19, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Giovanni S MolinariKarolina Kwasek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.