PMID: 8950743Nov 1, 1996Paper

Alanyl-glutamine-supplemented total parenteral nutrition improves survival and protein metabolism in rat protracted bacterial peritonitis model

JPEN. Journal of Parenteral and Enteral Nutrition
S NakaT Muto

Abstract

The effects of glutamine-enriched total parenteral nutrition (TPN) solution on survival, and protein turnover in the whole body and in individual organs were investigated in a rat protracted peritonitis model. Twenty-three rats underwent venous catheter insertion. Osmotic pumps were implanted in the peritoneal cavity to allow continuous delivery of Escherichia coli (4 x 10(8) CFU/d). The conventional TPN group received a conventional amino acid solution. The Ala-Gln TPN group received an alanyl-glutamine-enriched TPN solution. The two TPN solutions were isocaloric and isonitrogenous. Over the 5 days of TPN treatment, the survival rate of the Ala-Gln group was significantly higher than that of the conventional group. The Ala-Gln group tended to have increased whole-body protein turnover compared with the conventional group. Fractional protein synthetic rates (FSR) in the liver and gastrocnemius muscle of the Ala-Gln group were significantly higher than those of the conventional group. The serum glutamine concentration correlated positively with the FSR of both liver and muscle. The Ala-Gln group showed significantly greater mucosal height and mitoses per crypt, in the small intestine, than did the conventional group. Our results...Continue Reading

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Citations

Dec 3, 1999·Amino Acids·P C Calder, P Yaqoob
Nov 20, 2003·Nutrition·Rosângela Passos de Jesus MazzaDan Linetzky Waitzberg
Jul 31, 1998·Nutrition·D W Wilmore, J K Shabert
Feb 16, 2000·Nutrition·P C Calder
Mar 10, 2004·The British Journal of Nutrition·Sung-Ling YehWei-Jao Chen
Aug 12, 1998·The Journal of Surgical Research·A M EassonW W Souba
Jun 12, 2014·Revista do Colégio Brasileiro de Cirurgiões·Cibelle Ribeiro MagalhãesBruna Ayumi Harada
Sep 20, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Milan Holecek
Jul 8, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·P Fürst
Sep 14, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·H SaitoT Matsuda
Mar 30, 2005·Journal of Cellular Physiology·R CuriP Newsholme
Jul 1, 2006·Annals of Nutrition & Metabolism·Roman SafránekTomás Muthný
May 1, 2019·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Emanuele Therezinha Schueda StonogaSérgio Luiz Rocha
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·M J Rennie
Sep 28, 2002·Critical Care Medicine·Frantisek NovakXiangyao Su
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·I T Campbell
Jul 27, 1999·The Journal of Nutrition·S KewP C Calder
Dec 9, 1998·The American Journal of Physiology·J QuanS E Fleming

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