PMID: 6412274Jan 1, 1983Paper

Alaproclate: a pharmacokinetic and biochemical study in patients with dementia of Alzheimer type

Psychopharmacology
I BergmanL Svennerholm

Abstract

Alaproclate, a specific inhibitor of neuronal serotonin re-uptake, was given to 12 patients with dementia of Alzheimer type. The drug was rapidly absorbed and an elimination half-life of 7.1 +/- 0.9 h (+/- SD, n = 8) was calculated. Plasma protein binding for alaproclate was 82 +/- 1%. Two weeks of repeated administration produced plasma concentrations of alaproclate similar to those predicted from a single dose. The pharmacological effect of the drug was demonstrated by an inhibition of serotonin uptake in the patients' platelets and a reduction of the serotonin concentration in blood. Global rating of clinical efficacy showed a positive effect of alaproclate in five of the patients, mainly regarding emotional functions.

References

Dec 1, 1975·Journal of Pharmacokinetics and Biopharmaceutics·E J Triggs, R L Nation
Feb 20, 1982·Lancet·J S BentonJ S Snowden
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Citations

Jan 1, 1994·European Archives of Psychiatry and Clinical Neuroscience·J C Soares, S Gershon
Jan 11, 1992·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·P JäkäläP Riekkinen
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·P JäkäläP J Riekkinen
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·G L Wenk, D S Olton
May 1, 1987·Postgraduate Medical Journal·J M Orgogozo, R Spiegel
Mar 1, 1985·Acta Psychiatrica Scandinavica·A Aberg-WistedtH Wachtmeister
Oct 1, 1995·Journal of Geriatric Psychiatry and Neurology·P N TariotI R Katz
Dec 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·A L Nyth, C G Gottfries
Jul 1, 1988·Medicinal Research Reviews·W H MoosE R Gamzu

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