Albumin Administration in Acute Ischemic Stroke: Safety Analysis of the ALIAS Part 2 Multicenter Trial

PloS One
Michael D HillMyron D Ginsberg

Abstract

Albumin treatment of ischemic stroke was associated with cardiopulmonary adverse events in previous studies and a low incidence of intracranial hemorrhage. We sought to describe the neurological and cardiopulmonary adverse events in the ALIAS Part 2 Multicenter Trial. Ischemic stroke patients, aged 18-83 and a baseline NIHSS ≥ 6, were randomized to treatment with ALB or saline control within 5 hours of stroke onset. Neurological adverse events included symptomatic intracranial hemorrhage, hemicraniectomy, neurological deterioration and neurological death. Cardiopulmonary adverse events included pulmonary edema/congestive heart failure, acute coronary syndromes, atrial fibrillation, pneumonia and pulmonary thromboembolism. Among 830 patients, neurological and cardiopulmonary adverse events were not differentially associated with poor outcome between ALB and saline control subjects. The rate of symptomatic intracranial hemorrhage in the first 24h was low overall (2.9%, 24/830) but more common in the ALB treated subjects (RR = 2.4, CI95 1.01-5.8). The rate of pulmonary edema/CHF in the first 48h was 7.9% (59/830) and was more common among ALB treated subjects (RR = 10.7, CI95 4.3-26.6); this complication was expected and was satis...Continue Reading

Associated Clinical Trials

Oct 10, 2005·Myron GinsbergMyron Ginsberg

References

Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·Ludmila BelayevMyron D Ginsberg
Aug 19, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·Michael D HillUNKNOWN ALIAS Investigators
Sep 26, 2008·The New England Journal of Medicine·Werner HackeUNKNOWN ECASS Investigators
May 8, 2010·International Journal of Stroke : Official Journal of the International Stroke Society·C WeimarUNKNOWN VISTA Steering Committee
Dec 18, 2010·Stroke; a Journal of Cerebral Circulation·Myron D GinsbergUNKNOWN ALIAS Investigators
May 7, 2011·Stroke; a Journal of Cerebral Circulation·Michael D HillUNKNOWN Neurological Emergencies Treatment Trials Network
Feb 22, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Isabelle Beaulieu-BoireJean-Martin Boulanger
Jul 12, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Richard A DefazioMyron D Ginsberg
Jul 20, 2012·International Journal of Cardiology·Aristeidis H KatsanosSotirios Giannopoulos
Oct 12, 2012·European Neurology·J K JensenJ Ravkilde
Apr 10, 2013·The American Journal of Cardiology·Michal KrálDavid Školoudík
Sep 6, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Jennifer HannaUlf Schött
Oct 1, 2013·Lancet Neurology·Myron D GinsbergUNKNOWN ALIAS and Neurological Emergencies Treatment Trials (NETT) Investigators

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Citations

Nov 21, 2017·Biomarker Research·Shih-Chieh ChienHung-I Yeh
Jul 28, 2016·Stroke; a Journal of Cerebral Circulation·Renee' H MartinUNKNOWN ALIAS Parts 1 and 2 and NETT Investigators

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Methods Mentioned

BETA
X-ray

Software Mentioned

VISTA

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