Albumin and hemoglobin adducts of estrogen quinone as biomarkers for early detection of breast cancer

PloS One
Po-Hsiung LinDar-Ren Chen

Abstract

Cumulative estrogen concentration is an important determinant of the risk of developing breast cancer. Estrogen carcinogenesis is attributed to the combination of receptor-driven mitogenesis and DNA damage induced by quinonoid metabolites of estrogen. The present study was focused on developing an improved breast cancer prediction model using estrogen quinone-protein adduct concentrations. Blood samples from 152 breast cancer patients and 71 healthy women were collected, and albumin (Alb) and hemoglobin (Hb) adducts of estrogen-3,4-quinone and estrogen-2,3-quinone were extracted and evaluated as potential biomarkers of breast cancer. A multilayer perceptron (MLP) was used as the predictor model and the resultant prediction of breast cancer was more accurate than other existing detection methods. A MLP using the logarithm of the concentrations of the estrogen quinone-derived adducts (four input nodes, 10 hidden nodes, and one output node) was used to predict breast cancer risk with accuracy close to 100% and area under curve (AUC) close to one. The AUC value of one showed that both data sets were separable. We conclude that Alb and Hb adducts of estrogen quinones are promising biomarkers for the early detection of breast cancer.

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W H Wolberg, O L Mangasarian
Feb 1, 1993·Pharmacology & Therapeutics·C P Martucci, J Fishman
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·C L HayesT R Sutter
Nov 1, 1996·Carcinogenesis·H S Feigelson, B E Henderson
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·E L CavalieriE G Rogan
Jun 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·D C SpinkT R Sutter
Jun 13, 1998·Journal of the National Cancer Institute·G A Colditz
Aug 30, 2000·Journal of the National Cancer Institute. Monographs·J D Yager
Aug 30, 2000·Journal of the National Cancer Institute. Monographs·E CavalieriD Roy
Dec 8, 2000·Breast Cancer Research and Treatment·S H ChengA T Huang
Dec 11, 2002·Artificial Intelligence in Medicine·José M Jerez-AragonésEmilio Alba-Conejo
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer ListgartenBrent Zanke
Apr 13, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elieser GorelikAnna E Lokshin
Jan 20, 2006·The New England Journal of Medicine·James D Yager, Nancy E Davidson
Dec 7, 2007·Chemical Research in Toxicology·Judy L Bolton, Gregory R J Thatcher
Mar 3, 2009·Annals of the New York Academy of Sciences·Fritz F ParlPhilip S Crooke
May 30, 2009·BMC Cancer·Jonathan L JesneckJoseph Y Lo
Jan 5, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Chiun-Sheng HuangChen-Yang Shen
Jan 19, 2010·Breast Cancer Research : BCR·Jørgen AarøeAnne-Lise Børresen-Dale
Dec 7, 2013·BMC Bioinformatics·Mohsen HajilooSambasivarao Damaraju
Dec 29, 2013·BioMed Research International·Fan ZhangRenee Drabier
Feb 22, 2017·Diagnostics·Carlos E Galván-TejadaMargarita L Martinez-Fierro

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