PMID: 107929Feb 1, 1979

Albumin-coated Amberlite XAD-7 resin for hemoperfusion in acute liver failure. Part I: adsorption studies

Artificial Organs
H Y TonR Williams

Abstract

Platelets adhere to most foreign surfaces. As a result, polymers and albumin have been suggested as possible coatings to improve the blood compatibility of such surfaces. Amberlite XAD-7 has a high affinity for human serum albumin (HSA) and several protein-bound toxic metabolites. In the present study it is shown that HSA can be tightly bound to Amberlite XAD-7 without the use of chemical coupling agents. Optimal binding was achieved at pH 5.0 and the adsorption conforms to Langmuir's isotherm. Theoretical analysis of data and absence of a residual surface coating visible with scanning electron microscopy suggest a monolayer of albumin. The amount of HSA eluted from the resin under severe flow conditions was negligible (approximately 1%). Furthermore, in stirred batch studies with human plasma, the HSA coating did not decrease the adsorptive capacity of XAD-7 for bile acids and bilirubin.

References

Mar 1, 1976·Archives of Internal Medicine·J L RosenbaumR Raja
May 1, 1979·Journal of Biomedical Materials Research·H Y TonR Williams
Dec 1, 1969·Canadian Journal of Physiology and Pharmacology·T M Chang

Citations

Jan 1, 1984·Applied Biochemistry and Biotechnology·T M Chang
Sep 1, 1991·Digestive Diseases and Sciences·T TakahashiY Nosé
Aug 6, 2000·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Y T YuH Gu
May 11, 2006·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Stephen R AshDavid J Carr
Jan 28, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Stephen R AshT A Sullivan
Nov 1, 1983·Journal of Biomedical Materials Research·D M McPhillipsD R Owen
Nov 29, 2002·The International Journal of Artificial Organs·R D Hughes

Related Concepts

Acrylic Resins
Acute Disease
Adsorption
Carbodiimides
Sekumatic
Hemoperfusion
Liver Dysfunction
Plasma Albumin
Surface Properties
Physicochemical Phenomena

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