Albumin-covered lipid nanocapsules exhibit enhanced uptake performance by breast-tumor cells

Colloids and Surfaces. B, Biointerfaces
Francisco Galisteo-GonzalezJ A Marchal

Abstract

Liquid lipid nanocapsules (LLN) represent a promising new generation of drug-delivery systems. They can carry hydrophobic drugs in their oily core, but the composition and structure of the surrounding protective shell determine their capacity to survive in the circulatory system and to achieve their goal: penetrate tumor cells. Here, we present a study of LLN covered by the protein human serum albumin (HSA) and loaded with curcumin as a hydrophobic model drug. A cross-linking procedure was performed to further strengthen the protective protein layer. Physicochemical properties and release kinetics of the nanocapsules were investigated, and cellular uptake and killing capacity were evaluated on the human breast-cancer line MCF-7. The nanocapsules exhibited a half maximal inhibitory concentration (IC50) capacity similar to that of free curcumin, but avoiding problems associated with excipients, and displayed an outstanding uptake performance, entering cells massively in less than 1 min.

Citations

Dec 29, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Matheus de Castro LeãoInar Alves Castro
Feb 28, 2021·Food Chemistry·Aixa Aguilera-GarridoJulia Maldonado-Valderrama
Mar 6, 2021·Advances in Colloid and Interface Science·Aixa Aguilera-GarridoJulia Maldonado-Valderrama
Nov 5, 2021·Macromolecular Bioscience·Chengbin YangChih-Kuang Chen

❮ Previous
Next ❯

Related Concepts

Related Papers

Future Medicinal Chemistry
Angelica M MerlotDes R Richardson
Colloids and Surfaces. B, Biointerfaces
Teresa Del Castillo-SantaellaFrancisco Galisteo-Gonzalez
International Journal of Molecular Sciences
Paola Sánchez-MorenoJosé Manuel Peula-García
© 2022 Meta ULC. All rights reserved