PMID: 8584015Oct 4, 1995Paper

Albumin modified by Amadori glucose adducts activates mesangial cell type IV collagen gene transcription

Molecular and Cellular Biochemistry
M P CohenFuad N Ziyadeh

Abstract

The direct relationship between elevated glucose concentrations and accelerated protein glycation has implicated increased glycation as a potential mechanistic link between hyperglycemia and the pathogenesis of diabetic nephropathy. Albumin modified by Amadori glucose adducts has been shown to stimulate collagen secretion by mesangial cells in vitro, and to contribute to the overproduction of glomerular mesangial matrix in vivo. To delineate mechanisms responsible for these effects, we examined the influence of glycated albumin on transcriptional activation of the alpha 1 (IV) collagen gene in renal glomerular mesangial cells. These experiments used a stably transfected reporter mesangial cell line that exhibits responses to media manipulations that are directionally parallel with those of non-transformed mesangial cells, and that expresses luciferase driven by 5'-flanking and first intron regions of the alpha 1 (IV) collagen gene. In these cells, purified glycated albumin stimulated collagen IV gene transcription, whereas glucose-free albumin did not. Further, glycated albumin induced a significant increase in mesangial cell collagen IV mRNA, assessed by Northern blot analysis and quantified by calculation of the ratio of coll...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C E GuthrowJ W Baynes
Oct 1, 1992·Kidney International·M SabbatiniV E Andreucci
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H VlassaraR Bucala
Sep 1, 1989·Journal of Immunological Methods·M P Cohen, E Hud
Jul 1, 1988·The Journal of Cell Biology·N GhineaN Simionescu
Feb 8, 1989·Journal of Immunological Methods·M P Cohen, E Hud
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J E SchnitzerG E Palade
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Mar 1, 1983·Kidney International·J I Kreisberg, M J Karnovsky
Jan 28, 1994·Biochemical and Biophysical Research Communications·V Y Wu, M P Cohen
Feb 9, 1995·Molecular and Cellular Biochemistry·M P CohenF N Ziyadeh
Feb 15, 1995·Biochemical and Biophysical Research Communications·V Y Wu, M P Cohen
Feb 1, 1994·Kidney International·M P Cohen, F N Ziyadeh
Aug 11, 1993·Molecular and Cellular Biochemistry·F N Ziyadeh, M P Cohen
Jun 30, 1993·Biochemical and Biophysical Research Communications·V Y Wu, M P Cohen
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
May 8, 1993·Biochimica Et Biophysica Acta·S KrantzB Gromoll

❮ Previous
Next ❯

Citations

Mar 26, 1998·Nihon rinsho. Japanese journal of clinical medicine·Y Sakamoto
Nov 21, 2001·Current Opinion in Pharmacology·R E GilbertR C Atkins
Sep 21, 2000·Kidney International. Supplement·M Dunlop
Jun 9, 2001·Biochemical and Biophysical Research Communications·V Y WuM P Cohen
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·B CormanB I Levy
Oct 1, 2013·Journal of the American Academy of Dermatology·Supriya S VenugopalDedee F Murrell
May 25, 2002·Kidney International·Margo P CohenSheldon Chen
May 16, 2006·The Journal of Laboratory and Clinical Medicine·Margo P CohenSheldon Chen
Apr 20, 2010·Biochemical and Biophysical Research Communications·Yanzhang Li, Shuxia Wang
Jun 8, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria Felice BrizziPaolo Cavallo-Perin
May 18, 1999·The American Journal of Physiology·M P CohenC W Shearman
Nov 21, 2008·American Journal of Physiology. Renal Physiology·Xiao Fan WeiMin Liang
Dec 18, 2002·Experimental Biology and Medicine·Jingfei Cheng, Joseph P Grande
Jun 17, 2004·American Journal of Physiology. Renal Physiology·Hyun Soon LeeHye Kyoung Hong
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Roger M Mason, Nadia Abdel Wahab
Jul 25, 2000·Journal of the American Society of Nephrology : JASN·Laurent TeilletBruno Corman
Jan 27, 1998·Journal of Diabetes and Its Complications·R S ClementsM P Cohen
Oct 22, 2003·Archives of Biochemistry and Biophysics·Margo P Cohen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.