PMID: 2104980Jan 1, 1990Paper

Albumin Redhill (-1 Arg, 320 Ala----Thr): a glycoprotein variant of human serum albumin whose precursor has an aberrant signal peptidase cleavage site

Proceedings of the National Academy of Sciences of the United States of America
S O BrennanP M George

Abstract

Albumin Redhill is an electrophoretically slow genetic variant of human serum albumin that does not bind 63Ni2+ and has a molecular mass 2.5 kDa higher than normal albumin. Its inability to bind Ni2+ was explained by the finding of an additional residue of Arg at position -1. This did not explain the molecular basis of the genetic variation (since proalbumin contains adjacent Arg residues at -1 and -2) or the increase in apparent molecular mass. Fractionation of tryptic digests on concanavalin A-Sepharose followed by peptide mapping of the bound and unbound fractions and sequence analysis of the glycopeptides identified a mutation of 320 Ala----Thr. This introduces an Asn-Tyr-Thr oligosaccharide attachment sequence centered on Asn-318 and explains the increase in molecular mass. This, however, did not satisfactorily explain the presence of the additional Arg residue at position -1. DNA sequencing of polymerase chain reaction-amplified genomic DNA encoding the prepro sequence of albumin indicated an additional mutation of -2 Arg----Cys. This introduces a prepro sequence, Met-Lys-Trp-Val-Thr-Phe-Ile-Ser-Leu-Leu-Phe-Leu-Phe-Ser-Ser-Ala-Tyr- Ser-Arg-Gly-Val-Phe-Cys-Arg (cf.-Tyr-Ser-Arg-Gly-Val-Phe-Arg-Arg- in normal human pre-proal...Continue Reading

References

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Aug 31, 1978·Nature·S O Brennan, R W Carrell
Aug 31, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·S O BrennanR J Peach
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Nov 6, 1984·Biochimica Et Biophysica Acta·S O BrennanR W Carrell
Jan 31, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·S BrandD Donaldson
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Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J H Elder, S Alexander
Aug 31, 1981·FEBS Letters·Y AbdoM Dautrevaux

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Citations

Oct 6, 2000·Biochimica Et Biophysica Acta·S O Brennan, P M George
Dec 12, 2001·Biochimica Et Biophysica Acta·U Kragh-HansenP H Jensen
Aug 14, 1999·Biochimica Et Biophysica Acta·S O BrennanP M George
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K AraiF W Putnam
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S O BrennanF W Putnam
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J MadisonF W Putnam
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J CarlsonF W Putnam
Oct 20, 2015·Biotechnology and Bioengineering·Zahra Azimzadeh IraniJens Nielsen
Jan 11, 2012·Molecular Aspects of Medicine·Gabriella FanaliPaolo Ascenzi
Dec 27, 2008·Biochimica Et Biophysica Acta·Yasunori IwaoMasaki Otagiri
May 7, 2008·Human Mutation·Lorenzo MinchiottiTheodore Peters
Feb 1, 2005·Biochimica Et Biophysica Acta·Ulrich Kragh-HansenMasaki Otagiri
May 1, 1993·International Journal of Peptide and Protein Research·W C ZanC W Chi
Oct 27, 1997·The Journal of Biological Chemistry·R Meech, P I Mackenzie

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