Albumin supplementation in the critically ill. A prospective, randomized trial

Archives of Surgery
E F FoleyP N Benotti

Abstract

Albumin replacement to correct hypoalbuminemia in critically ill patients has been controversial. This study was a prospective, randomized trial of 25% albumin administration in 40 hypoalbuminemic (serum albumin, less than 25 g/L [2.5 g/dL]), critically ill patients. The treatment group (18 patients) received 25% albumin supplementation to achieve and maintain serum albumin levels of 25 g/L (2.5 g/dL) or greater, while the nontreatment group (22 patients) received no concentrated albumin. There was no clinical benefit from albumin therapy when assessing mortality (39% vs 27%, treatment vs control) or major complication rate (89% vs 77% of patients). There were also no significant differences in length of hospital stay, intensive care unit stay, ventilator dependence, or tolerance of enteral feeding, despite significant elevations of albumin in the treatment group. The costly use of exogenous albumin as treatment for hypoalbuminemia in this patient population does not appear to be justified.

Citations

Apr 16, 1998·Intensive Care Medicine·J BoldtM Papsdorf
Jul 24, 1998·BMJ : British Medical Journal·UNKNOWN Cochrane Injuries Group Albumin Reviewers
Mar 20, 2001·Critical Care : the Official Journal of the Critical Care Forum·A R Webb
Mar 20, 2001·Critical Care : the Official Journal of the Critical Care Forum·J L Vincent
Apr 30, 2003·Archives of Disease in Childhood·A DurwardI A Murdoch
Jul 9, 2004·Wiener klinische Wochenschrift·Thiemo F VenemanArend J J Woittiez
Apr 11, 2003·AIDS Clinical Care·Eric S Rosenberg
Jun 1, 1997·Disease-a-month : DM·B A Mizock, S Troglia
Oct 14, 2008·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Annette BisanzEduardo Bruera
Feb 26, 1999·Transfusion·J J Skillman
Jan 28, 2004·Cell Structure and Function·Kaoru TakegawaNaotaka Tanaka
Nov 26, 2004·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society
Aug 11, 2007·Expert Opinion on Drug Safety·Byron ChalidisPeter V Giannoudis
Dec 8, 2009·Transfusion Medicine Reviews·Albert Farrugia
Dec 23, 2008·Nutrition·Melissa M Chan, Gary M Chan
Aug 25, 2010·Journal of Veterinary Emergency and Critical Care·Sara J SnowAndrew J Brown
Apr 1, 1994·The Annals of Pharmacotherapy·R G D'Angio
Oct 14, 2008·Surgery·Manjunath Haridas, Mark A Malangoni
Aug 25, 2004·Clinics in Perinatology·Michael R Uhing
Jul 1, 2017·British Journal of Neurosurgery·Ankur KapoorKanchan K Mukherjee
Mar 1, 1995·JPEN. Journal of Parenteral and Enteral Nutrition·R L Koretz
Nov 7, 2000·British Journal of Anaesthesia·J P NicholsonG R Park
Nov 7, 2012·Journal of Burn Care & Research : Official Publication of the American Burn Association·Alex MelinyshynRobert Cartotto
Nov 13, 2012·Journal of Burn Care & Research : Official Publication of the American Burn Association·Robert Cartotto, Jeannie Callum
Oct 6, 1997·The Journal of Trauma·R L SheridanJ J Cunningham
Nov 3, 1998·Anaesthesia·M P Margarson, N Soni
Dec 1, 1998·Journal of Clinical Pharmacy and Therapeutics·S NatschY A Hekster
Nov 11, 2011·The Cochrane Database of Systematic Reviews·Ian RobertsGillian Schierhout
Sep 15, 2012·Journal of the Korean Surgical Society·Song Soo YangJin Cheon Kim
Sep 1, 2007·Current Opinion in Critical Care·Sean M Bagshaw, Rinaldo Bellomo
Apr 3, 2008·Journal of the American Veterinary Medical Association·Linda G MartinStephen A Hines
Jun 14, 2003·European Journal of Anaesthesiology·G Marx
Dec 20, 2005·Obstetrical & Gynecological Survey·Joseph T SantosoKen Grosshart
May 10, 2001·Journal of the American Veterinary Medical Association·J C LoganU Giger
Aug 1, 1996·Anesthesia and Analgesia·R J Traylor, R G Pearl
Jun 1, 1995·Obstetrical & Gynecological Survey·J T SantosoD S Miller
Sep 16, 2016·Critical Care Medicine·Jose I SuarezSimon Finfer
Aug 24, 2017·Critical Care Nursing Quarterly·Whitney GrossLauren A Kimmons

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.